Biochemical profile of multiple myeloma about 50 cases
1 Biochemistry and toxicology laboratory, Avicenna Military Hospital Marrakesh.
2 Faculty of medicine and pharmacy - Cadi Ayyad University Marrakesh.
3 Hematology Department, Avicenna Military Hospital, Marrakesh, Morocco.
Research Article
GSC Advanced Research and Reviews, 2021, 09(03), 145–150.
Article DOI: 10.30574/gscarr.2021.9.3.0302
Publication history:
Received on 19 November 2021; revised on 28 December 2021; accepted on 30 December 2021
Abstract:
Multiple myeloma (MM) is a clonal proliferation of plasma cells invading the bone marrow and secreting monoclonal immunoglobulin. In order to study the epidemiological and biological and biochemical characteristics of MM, we carried out a retrospective work on a cohort of 50 cases collected at the Avicenna Military Hospital in Marrakesh, during a period of 5 years (from January 2013 to December 2017). Our study included 32 men (64%) and 18 women (36%), with an average age of 60.6 years, with extremes at 44 and 87 years. The circumstances of discovery were dominated by bone pain and alteration in general condition, which are revealing in more than 65% of cases. Biologically: the sedimentation rate was accelerated in 86% of cases, a monoclonal peak appearance was revealed on serum proteins electrophoresis in 88%of cases, most often located in the γ zone (64%), a predominance of the Ig G isotype (64%), and kappa light chains in 60% of cases, Bence Jones protein (BJP) was found in 7 patients, i.e. 14% of cases, and plasmacytosis over 10% was found on the myelograms in 90 % of cases.
Keywords:
Multiple myeloma; electrophoresis; monoclonal peak; Ig G; light chains; Bence Jones protein
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