A comprehensive review about the relationship between sodium and insulin resistance
Pathological analysis department, College of Science, Al-Qasim Green University, Babylon, 51013, Iraq.
Review Article
GSC Advanced Research and Reviews, 2025, 22(02), 035–038.
Article DOI: 10.30574/gscarr.2025.22.2.0033
Publication history:
Received on 22 December 2024; revised on 02 February 2025; accepted on 05 February 2025
Abstract:
Sodium plays a critical role in various physiological processes, including fluid balance, nerve transmission, and muscle function. However, its impact on insulin resistance has garnered significant attention in recent research. Elevated sodium intake has been linked to metabolic dysfunction, contributing to the development of insulin resistance, a hallmark of type 2 diabetes and metabolic syndrome. High sodium levels may influence insulin signaling pathways, promote oxidative stress, and exacerbate inflammation, thereby impairing glucose uptake by peripheral tissues. Additionally, excessive sodium consumption is associated with increased blood pressure, which further aggravates metabolic disturbances. Conversely, studies suggest that sodium restriction may improve insulin sensitivity and reduce the risk of diabetes-related complications. This abstract highlight the need for a deeper understanding of the molecular mechanisms underlying the sodium-insulin resistance connection and the importance of dietary sodium regulation in metabolic health.
Keywords:
Sodium; Insulin Resistance; RASS; Diabetes and Obesity
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Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
