Lipid-based nanoparticles and their recent advances
Department of Pharmaceutics, Satavahana University, Telangana 505002, India.
Review Article
GSC Advanced Research and Reviews, 2024, 18(03), 182–188.
Article DOI: 10.30574/gscarr.2024.18.3.0096
Publication history:
Received on 01 February 2024; revised on 06 March 2024; accepted on 09 March 2024
Abstract:
Lipid-based nanoparticles hold great potential for drug delivery, providing biocompatibility and the ability to encapsulate both hydrophilic and hydrophobic drugs. However, there are certain challenges associated with small molecules, such as leakage and premature release, which can compromise their effectiveness. Despite these challenges, lipid nanoparticles offer advantages in terms of solubility, stability, and targeted delivery, thereby reducing side effects. Additionally, they can be customized for specific molecules, ensuring biocompatibility and biodegradability. While complications may arise, lipid nanoparticles offer numerous benefits for loading biomolecules, improving pharmacokinetics, and enhancing therapeutic effects. It is important to address stability and loading challenges when encapsulating biomolecules and consider potential immunogenic responses that may impact biocompatibility and safety.
Keywords:
Nanoparticles; Drug delivery; Lipid-based nanoparticles; Solubility
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
