In-vitro anti-inflammatory, anti-oxidant and In-vivo anti-urolithiatic activities of Coccinia grandis fruit extract
Department of Pharmacology, Faculty of Pharmacy, Aditya University, Surampalem, Andhra Pradesh, India.
Research Article
GSC Advanced Research and Reviews, 2024, 21(01), 463–469.
Article DOI: 10.30574/gscarr.2024.21.1.0399
Publication history:
Received on 15 September 2024; revised on 23 October 2024; accepted on 26 October 2024
Abstract:
This research study was performed to evaluate the in-vitro anti-oxidant, anti-inflammatory and in-vivo activities of ethanolic fruit extract of Coccinia grandis. The fruit extract of Coccinia grandis at a concentration of 100 µg/ml was tested for its free radical scavenging activity adopting the standard methods like DPPH and Nitric Oxide. In-vitro anti-inflammatory activity was determined using Protein Denaturation Method and Human Red Blood Cells Method using Coccinia grandis. Further, In-vivo anti-urolithiatic activity was carried out by administering 0.75% of Ethylene Glycol solution to male rats for drinking, which caused urolithiasis. Coccinia grandis fruit extract exhibited significant anti-oxidant, anti-inflammatory and anti-urolithiatic activities. The results indicate that the extract possessed good therapeutic potential.
Keywords:
Coccinia grandis; Anti-oxidant; Anti-inflammatory; Anti-urolithiasis; Ethylene glycol; Human Red Blood Cells method
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