Нyperdiploid мultiple мyeloma-cytogenetic and clinical aspects
1 Department of Hematology, Military Medical Academy, Sofia, Bulgaria.
2 Laboratory of Cytogenetics and Molecular biology, Military Medical Academy, Sofia, Bulgaria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 26(02), 135–139.
Article DOI: 10.30574/gscbps.2024.26.2.0053
Publication history:
Received on 27 December 2023; revised on 07 February 2024; accepted on 09 February 2024
Abstract:
In the current research the attention is focused on the possibilities of identifying a hyperdiploidy myeloma clone (HdMC) by using a triple-color fluorescence “in situ” hybridization (FISH) probe. The cytogenetic results from the bone marrow aspirates of 26 patients with newly diagnosed multiple myeloma admitted in the Hematology Department of our hospital during the period from March to September 2023 have been analyzed. The group consists of 12 female and 14 male patients with an average age of 67 years. A FISH probe for establishing hyperdiploidy myeloma clone was used as well as the most common methods for detecting genetic aberrations affecting the long and short arms of the 1 and 14q32 chromosome rearrangements. According to the results, two subgroups of patients have been established. The first subgroup consists of the patients with positive FISH probes for hyperdiploidy myeloma and/or 14q34 rearrangements and 1q25/1p36, while the second one consists of patients, negative for all the three probes listed above. A comparison between the demographic, laboratory data and the ISS (International Staging System) stage of the two subgroups has been made. The collected data suggests that the use of the triple-color FISH probe, as well as some other factors in the analyzed information, increases the probability of detecting a HdMC by 23%.
Keywords:
Multiple myeloma; Hyperdiploidy clone; FISH; Triple-color probe
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
