Advance in gold nanoparticle- mediated drug delivery system

Shriyog V Amalkar, Pooja R Hatwar *, Ravindra L Bakal and Nitin B Kohale

Department of Pharmaceutics, Shri Swami Samarth Institute of Pharmacy, At Parsodi, Dhamangoan Rly, Dist -Amravati (444709) Maharashtra, India.
 
Review Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(03), 169–179.
Article DOI: 10.30574/gscbps.2024.28.3.0324
Publication history: 
Received on 03 August 2024; revised on 14 September 2024; accepted on 16 September 2024
 
Abstract: 
Gold nanoparticles (AuNPs) have emerged as versatile platforms for biomedical applications, particularly in cancer research, diagnostics, and therapy. AuNPs exhibit unique optical, electrical, and photothermal properties, making them ideal for sensing, imaging, and targeted therapy. Recent advancements in AuNP synthesis methods, characterization techniques, and applications are highlighted. Various methods, including chemical reduction, green synthesis, and hydrothermal synthesis, can produce AuNPs with controlled sizes and shapes. AuNPs have shown potential in cancer treatment, including ferroptosis induction, drug delivery, and imaging. However, limitations remain concerns. Future directions focus on enhancing stability, biocompatibility, targeting, and drug delivery capacity. AuNP-mediated drug delivery systems offer advantages over traditional medications and other nanocarriers.
 
Keywords: 
Gold Nanoparticles; Synthesis; Biomedical applications; Ferroptosis; Lipid Metabolism
 
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