Antioxidant and antiamylase activities of leaf and root extracts of Ziziphus mauritiana Lam
1 Department of Biology, Faculty of Sciences and Technology (FST), University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
2 Africain Centre of Excellence in Bioinformatics and data Science (ACE-B), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(03), 084–090.
Article DOI: 10.30574/gscbps.2024.28.3.0297
Publication history:
Received on 29 June 2024; revised on 30 August 2024; accepted on 02 September 2024
Abstract:
Ziziphus mauritiana Lam is a plant species widely used in Mali for its medical virtues to treat various diseases including Diabetes. The present study aims to examine the antioxidant and antidiabetic activities of leaf and root extracts of Z. mauritiana Lam collected in Bamako. Phytochemical screening and assay were carried out using conventional methods. The DPPH test was used to evaluate the anti-radical activity, and the antidiabetic potential of the extracts was estimated via the α-amylase inhibition test. Characterization tests revealed the presence of free tannins, flavonoids, coumarins, terpenoids, triterpenes, alkaloids, saponins and anthraquinones in all our extracts. The root extracts revealed higher contents of polyphenols (561.40±22.4 to 218.00±30.2 mg EAG/g) and flavonoids (54.26±4.9 to 132.56±6, 82 mg EQ/g) whatever the solvent, with the exception of Ethyl Acetate. Ethanol extracts showed the best anti-radical potentiel. The IC50was 58.13±1.85 µg/mL for roots and 85.19±0.415 µg/mL for leaves. The results provide a better understanding of the medicinal properties of Z. mauritiana Lam and pave the way for management strategies for diabetes and diseases associated with oxidative stress.
Keywords:
Ziziphus mauritiana; Antidiabetic and antioxidant activities; α-Amylase inhibition; Hyperglycemia
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
