Cellular backpacks for macrophage immunotherapy- A Review
Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530049.
Review Article
GSC Biological and Pharmaceutical Sciences, 2022, 20(01), 126–133.
Article DOI: 10.30574/gscbps.2022.20.1.0283
Publication history:
Received on 06June 2022; revised on 06 July 2022; accepted on 08 July 2022
Abstract:
Worldwide, the most feared disease is cancer and more than 10 million people fall prey to it every year. For curing a disease, destroying the agent causing disease is required in the host, within the same environment. The utmost promising treatment is immunotherapy for cancer, and it has set a new pattern leading to many breakthroughs. Compared with norms of care such as chemotherapy, radiotherapy and surgery; immunotherapies like adoptive cellular immunotherapy, antibodies, vaccines, immune checkpoint inhibitors have achieved great heights in terms of its success rate and has brought remarkable growth in terms of quality of life and survival. There are limitations like adverse effects, inconsistent efficiency, and with regards to cancer low resistance and antitumor response rate, despite all the progress made. Between the in-built and adaptive immunity, co-operation is very crucial, for a long-lasting and efficacious antitumor response. Therapeutic approaches combined or based with macrophages were made in order to bypass these challenges, for the better treatment of various therapies to cure and reduce the severity of cancer. The role of macrophages and backpacks with the advancement of nanotechnology in current immunotherapy is vital for drug administration and will be an asset in the present era.
Keywords:
Cellular Backpacks; Macrophages; Immunotherapy; Chimeric antigen receptor (CAR) -T cell therapy
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
