Circadian cycle genes and their association with depression
Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Durango, Dgo, México.
2 Department of Genetics, Universidad Juárez del Estado de Durango, Durango, Dgo., México.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 29(03), 017–021.
Article DOI: 10.30574/gscbps.2024.29.3.0454
Publication history:
Received on 26 October 2024; revised on 02 December 2024; accepted on 04 December 2024
Abstract:
This work delves into the complex role of circadian-regulating genes and their relationship with depression, emphasizing key genes such as CLOCK, BMAL1, PER, and CRY that control biological rhythms. Genetic variations in these genes can lead to circadian disruptions, manifesting as insomnia, hormonal imbalances, and depression. This study highlights the critical role of melatonin, regulated by light exposure, in circadian alignment. Dysfunctional circadian regulation affects neurotransmitter secretion, particularly serotonin and dopamine, thereby impacting mood. This paper also discusses the influence of norepinephrine, GABA, glutamate, and genetic variants in serotonin pathways on mood disorders and their potential for targeted therapeutic interventions.
Keywords:
CLOCK; Circadian cycle; Melatonin; Depression; Cortisol; Serotonin; Neurotransmitters; Genetic variants.
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Copyright information:
Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
