Conscious sedation by Midazolam in pediatric odontology: A randomized clinical trial
1 Department of Pediatric Odontology, Dental Medicine Faculty, Hassan II University, Casablanca, 21100 Morocco.
2Pediatric Resuscitation, Private Practice.
Research Article
GSC Biological and Pharmaceutical Sciences, 2021, 14(02), 172-180.
Article DOI: 10.30574/gscbps.2021.14.2.0056
Publication history:
Received on 19 January 2021; revised on 20 February 2021; accepted on 22 February 2021
Abstract:
Objectives: The objectives of this study are to evaluate the efficacy of midazolam as a means of conscious sedation in pediatric odontology through three routes of administration: oral, rectal and nasal administration, to compare the efficacy of these different routes and to assess the general safety of Midazolam.
Materials and Methods: Thirty healthy non-cooperating (ASAI) patients (levels 1 and 2 on the FRANKL scale), aged 2 to 5 years and requiring a minimum of three dental sessions were recruited. Each patient received three sessions of sedation, using a different route of administration each time: oral (0.5 mg/kg), rectal (0.3 mg/kg) and nasal (0.2 mg/kg). The assessment of the behavior throughout the dental care was made using the Houpt scale. Physiological parameters(heart rate and oxygen saturation) were measured every five minutes to assess tolerance.
Results: The three routes of administration of midazolam were considered effective since all patients presented a behavior allowing a complete management without interruption of care except for one patient. The sedative effect of the oral and rectal routes was similar, as to the nasal route, it was judged to be clinically better but without any statistically significant differences. The most accepted route of administration by patients was the oral one followed by the nasal and rectal routes. No intolerance to midazolam was observed.
Conclusion: Midazolam is an effective sedative for dental care, acceptable by patients and well tolerated regardless of the route of administration.
Keywords:
Conscious sedation; Midazolam; Oral; Intranasal; Rectal; Child; Dentistry
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Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
