Evaluation of diuretic activity of hydro ethanolic extract of Passiflora edulis f edulis (PASSIFLORACEAE) leaves in rat
1 Laboratory of Biotechnology Research Environment and Health, Doctoral School of Engineering Living and Modeling (EDGVM), Faculty of Sciences Technology and Environment, University of Mahajanga, Madagascar.
2 Department of Pharmacology, Sciences Faculty, BP 906, University of Antananarivo, Madagascar.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 29(02), 408–413.
Article DOI: 10.30574/gscbps.2024.29.2.0447
Publication history:
Received on 16 October 2024; revised on 26 November 2024; accepted on 28 November 2024
Abstract:
Passiflora edulis Sims is widely used in traditional medicine in many countries worldwide for the treatment of diverse diseases due to its scientifically demonstrated antitumor, anti-inflammatory and antihypertensive effects; however, no preclinical studies have been done on the diuretic activity of the hydro ethanolic extract from P. edulis leaves in rats. The objective of this work was to study the diuretic activity of the above-mentioned extract in rats. Oral administration of the extract at doses 75, 150 and 300 mg/kg increases diuresis which is equal to 3.3 ± 0.20 ml in the control animals, versus 4.56 ± 0.34, 5.7 ± 0.10 and 7.96 ± 0.37 ml in the animals treated with the extract (p < 0.05). Natriuresis of the animals treated with the extract increases to 0.91 ± 0.02, 1.07 ± 0.07 and 1.24 ± 0.23 mEq/L respectively, versus 0.77 ± 0.06 mEq/L in the control group (p < 0.05), while kaliuresis increases from 0.31 ± 0.01 mEq/L in the control group to 0.36 ± 0.02, 0.55 ± 0.04 and 0.88 ± 0.05 mEq/L in the animals treated with the extract (p < 0.05). Administration of extract does not affect the urine pH which is equal to 8.13 ± 0.51 in the control animals, versus 8.65 ± 0.47, 8.81 ± 0.5 and 8.83 ± 0.48 in the animals treated with the extract (NS). These results indicate the diuretic effect of hydro ethanolic extract of Passiflora edulis leaves.
Keywords:
Diuretic; Kaliuresis; Natriuresis; Rats
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