Hepatoprotective activity of Tridecan-1-ol isolatedfrom Flaveria trinervia (Speng). C. Mohr
1 Department of Phytochemistry and Pharmacology Trans Disciplinary Research Foundation Shankaraghatta–577 115, Karnataka, India.
2 Department of P.G. Studies and Research in Biotechnology and Bioinformatics, School of Biological Sciences, Kuvempu University, Shankaraghatta–577451, Karnataka, India.
3 Department of P.G. Studies and Research in Microbiology, Davanagere University, Tholahunase- 577002 Davanagere, Karnataka, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2023, 22(03), 271–279.
Article DOI: 10.30574/gscbps.2023.22.3.0093
Publication history:
Received on 28 December 2022; revised on 13 March 2023; accepted on 16 March 2023
Abstract:
Background- Flaveria trinervia (Asteraceae), a medicinal herb has been used in Indian traditionl medicine to cure jaundice. Reports on phytochemical and pharmacological investigations are very scarce. A phytoconstiuent Tridecan-1-ol and screened for hepatoprotective activity. -To evaluate hepatoprotective effects of Tridecan-1-ol against CCl4 induced hepatic damage on Wister albino rats.
Methods- Tridecan-1-ol was isolated from petroleum extract of Flaveria trinervia using silica gel column chromatography and the structure was confirmed by IR, MASS,and 1H NMR spectroscopic studies. The parameters employed to confirm the hepatoprotectivity were the estimation of liver function serum markers such as total bilirubin, total protein, alanine transaminase, aspartate transaminase, alkaline phosphatase activities and the histological profile of the liver tissue.
Results-The LD50 of petroleum ether extract and the constituent Tridecan -1-ol was found to be 500 and 150 mg/kg body weight respectively. Tridecan -1-ol showed significant hepatoprotective activity than the crude extract and it was compared with the standard hepatoprotective drug silymarin. The histological profile of the liver tissue ofTridecan-1-ol administered rats showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration as similar to the controls.
Conclusion-Tridecan-1-ol afforded significant hepatoprotectivity against CCl4 induced liver damage and supported the traditional claim of Flaveria trinervia as a hepatoprotective herb.
Keywords:
Flaveria trinervia; Hepatoprotective; Tridecan -1-ol; CCl4
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