Medicinal plants possessed anti-Parkinsonian effects with emphasis on their mechanisms of action
Dept. of Pharmacology, College of Medicine, University of Thi-Qar, Iraq.
Review Article
GSC Biological and Pharmaceutical Sciences, 2021, 17(01), 232–237.
Article DOI: 10.30574/gscbps.2021.17.1.0320
Publication history:
Received on 23 September 2021; revised on 27 October 2021; accepted on 29 October 2021
Abstract:
Parkinsonʼs disease is a progressive neurodegenerative dysfunction characterized by the loss of dopaminergic neurons of the nigrostriatal system. Dopamine is important to maintain normal movement patterns. The cardinal physical signs of the disease are distal resting tremor, rigidity, bradykinesia, and asymmetric onset. Treatment aims to improve these motor symptoms. Many medicinal plants possessed Parkinsonian effects by different mechanisms, included inhibition of α-synuclein condensation, reduction of oxidative stress and neuro-inflammation, increase of dopaminergic neurons survival, blockade of the adenosine A2A receptor and regulation of molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-κB, thus exerted neuroprotective actions. In the present review, we highlight the medicinal plants with potential anti-Parkinsonian effects with discussing the mechanisms of their beneficial effects.
Keywords:
Medicinal plants; Parkinsonʼs disease; Anti-Parkinsonian; Mechanisms
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Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
