Phytochemical and bioactive compounds identification of Ficus auriculata fig methanolic extraction and its antioxidant activity
Department of Pharmacy Shri JJT University, Jhunjhunu, Rajasthan, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 21(02), 246-254.
Article DOI: 10.30574/gscbps.2022.21.2.0453
Publication history:
Received on 20 October 2022; revised on 25 November 2022; accepted on 28 November 2022
Abstract:
In the current investigation, a new phytoconstituent was isolated and identified from a methanolic extract of Ficus auriculata Lour figs. Naturally occurring phytoconstituents have been used to treat ailments for a long time and have served as a source of structural variety for natural product chemists. Natural products are frequently mentioned as a rich source of chemical variation when looking for new pharmacological leads or molecules. The analysis of the chemical components of the methanolic extract led to the discovery of a new phytoconstituent, 5-hydroxy-2-(4-hydroxy-2-methyl-2H-pyran-6-yl)-9-methyl-2H,3H,4H-naphtho[1,2-b] pyran-4-one, with pyran as a basic nucleus. Ficus auriculata Lour figs were collected and sun-dried. Dried Ficus auriculata Lour figs were extracted using menthol. Ficus auriculata Lour figs methanolic extract conducted a preliminary phytochemical study. Ficus auriculata Lour figs methanolic extract novel phytoconstituent isolated and identified by using FT-IR, 1HNMR, 13CNMR, and MS were used to determine the compound's structure. Methanolic extract conducted antioxidant activity by the DPPH method. Preliminary screening confirmed that methanolic extract contains flavonoids and phenols. The purity of the 5-hydroxy-2-(4-hydroxy-2-methyl-2H-pyran-6-yl)-9-methyl-2H,3H,4H-naphtho[1,2-b] pyran-4-one compound was confirmed by RP-HPLC. 5-hydroxy-2-(4-hydroxy-2-methyl-2H-pyran-6-yl)-9-methyl-2H,3H,4H-naphtho[1,2-b]pyran-4-one compound were novel and first reported in Ficus auriculata Lour methanolic extract in the Ficus family. Based on previous studies, pyran moieties have a significant role in biological activities. Methanolic extract showed good antioxidant activity as compared to ascorbic acid. From the methanolic extract of the Ficus auriculata Lour fig, the chemical A, 5-hydroxy-2-(4-hydroxy-2-methyl-2H-pyran-6-yl)-9-methyl-2H,3H,4H-naphtho[1,2-b] pyran-4-one, was successfully isolated and identified. FT-IR, 1HNMR, 13CNMR, and LC-MS/MS spectral data were used to determine the novel compound's structure. Methanolic extract of Ficus auriculata Lour fig showing good antioxidant activity.
Keywords:
Ficus auriculata; Methanolic extract; DPPH assay; Phytoconstituent; LC-MS; NMR; TLC
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