Preparation and evaluation of sustained release microspheres for the treatment of diabetic neuropathy
Department of Pharmaceutics, Centre for Pharmaceutical Sciences, JNTUH UCESTH, JNTUH, Hyderabad, Telangana-500085, India.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 28(03), 197–208.
Article DOI: 10.30574/gscbps.2024.28.3.0335
Publication history:
Received on 11 August 2024; revised on 22 September 2024; accepted on 24 September 2024
Abstract:
This study aimed to prepare and evaluate sustained release microspheres for the treatment of diabetic neuropathy using Various polymers including sodium alginate, ethyl cellulose, HPMC K100, Carbopol 934, and Eudragit L-100-55. Polymers were employed to assess their impact on several crucial parameter’s entrapment efficiency, production yield Particle size analysis, swelling index, in vitro dissolution, and release kinetics. The production yield of microspheres varied depending on the polymer used, with some polymers performing in advanced yields. Entrapment effectiveness was set up to be optimal with certain polymer combinations. Particle size analysis indicated that the microspheres were within the asked range for controlled release operations. The swelling index showed polymer-dependent lump actions. In vitro dissolution studies demonstrated sustained medicine release over time, with different polymers impacting both the release rate and profile. medicine release kinetics analysis revealed that the release followed specific models, reflecting the commerce between the microsphere matrix and the medicine.
Keywords:
Microsphere; Sodium Alginate; HPMC K100; Carbopol 934; Eudragit L-100-55
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
