Renal and electrolyte profiles of Wistar albino rats fed with Irvingia wombolu kernel powder and its oil extract
Department of biochemistry, KOgi State University, Anyigba, Nigeria.
Research Article
GSC Biological and Pharmaceutical Sciences, 2022, 21(02), 180-185.
Article DOI: 10.30574/gscbps.2022.21.2.0366
Publication history:
Received on 06 October 2022; revised on 13 November 2022; accepted on 16 November 2022
Abstract:
Irvingia gabonensis Kernel powder and the oil extracts with and without testa (±testa)were mixed with commercial animal feed (50:50)and fed to groups of animals. Animals in groups A and B were fed with the powder at an equivalent concentration of 67mg/kg body weight while those in groups C and D were fed with the equivalent4ml of the oil extract in the mixture. Animals in group E, the control, were fed on the commercial feed only. All the animals were fed in an aluminum cage for 21 days and sacrificed the following day. Blood from the jugular vein was collected in universal bottles and used for determination of creatinine, urea, sodium, potassium and bicarbonate. It was observed that all the treated groups and the control showed no significant difference (P≥0.05) in their Nak concentrations. There were significant differences(p≤ 0.05) in the K+ concentrations between groups A,B, E and groups C, D respectively .Significant statistical differences(P≤0.05) were also observed in the creatinine concentrations of all the treated groups with the exception of group C. There were higher urea concentrations in groups C and D than A, B and E(P≤0.05).Bicarbonate showed the least concentration in group E with relatively higher concentrations in groups C and D(P≤0.05)
Keywords:
Irvingia gabonensis; Testa;Urea; Creatinine
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