Polymeric nanoparticles with stimuli-responsive properties for drug delivery
Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530049.
Review Article
GSC Biological and Pharmaceutical Sciences, 2022, 20(01), 044–055.
Article DOI: 10.30574/gscbps.2022.20.1.0259
Publication history:
Received on 23 May 2022; revised on 03 July 2022; accepted on 05 July 2022
Abstract:
In the last few decades, polymeric nanoparticles have been emerged as a most promising and viable technology for targeted and controlled delivery of drugs as well as delivery of bioactive compounds such as genes, drugs, nucleic acids and proteins among other things, in biomedical and pharmaceutical applications. They not only improve the solubility, bioavailability, and circulation time of previous medications, but they can also be tailor made to selectively release the drug at the target site. Furthermore, these polymeric nanoparticles can be transformed into stimuli sensitive systems based on either exogenous stimuli (such as ultrasound, light, electric pulses, magnetism) or by endogenous stimuli (such as PH, redox, enzymes, temperature, hypoxia, glucose) for efficient targeting and biodistribution of genes and drugs at specific sites. Polymeric nanoparticles for delivery of drugs and bioimaging has attained a considerable interest in various cancer therapies. In the present content, we discuss various types of stimuli-responsive-nanocarriers and their applications in different fields like bioimaging, drug delivery.,etc.
Keywords:
Stimuli-Responsive DDS; External Stimuli; Internal Stimuli; Bio Imaging; Gene Delivery; Drug Delivery
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
