Administration of ethanol extract of galangal (Alpinia Galanga) on histopathology of male mouse (Mus musculus) lungs exposed to lead acetate
Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya Indonesia.
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 26(03), 205–211
Article DOI: 10.30574/gscbps.2024.26.3.0109
Publication history:
Received on 17 February 2024; revised on 25 March 2024; accepted on 28 March 2024
Abstract:
Objective: This research aims to assess the preventive effect of ethanol extract of red galangal (Alpinia Galanga) on type I pneumocyte cell necrosis and proliferation of type II pulmonary pneumocytes in male mice (Mus musculus) exposed to lead acetate-induced damage.
Method: A total of 25 male mice aged 2.5-3 months and weighing 25-30 g were divided into five groups. The negative control group (K-) received oral water without lead acetate exposure, while the positive control group (K+) received 20 mg/kg BW of lead acetate. The treatment groups P1, P2, and P3 were exposed to lead acetate at a dose of 20 mg/kg BW/day and received red galangal extract at doses of 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW, respectively. All treatment groups were administered lead and ethanol extract of galangal orally from days 4 to 24 at a rate of 0.2 ml/head.
Results: The Mann-Whitney U statistical test revealed a significant increase in type I pneumocyte cell necrosis and type II pneumocyte cell proliferation in the lungs of male mice (Mus musculus) exposed to lead acetate (p<0.05). Administration of ethanol extract of galangal after exposure to lead acetate significantly reduced type I pneumocyte cell necrosis and type II pneumocyte cell proliferation (p<0.05). The highest dose of galangal ethanol extract, 800 mg/kg BW, showed a significant decrease in type II pneumocyte cell proliferation (p<0.05).
Conclusion: This study concludes that red galangal extract has a preventive effect in reducing the damage to type I and type II pneumocytes in the lungs of male mice (Mus musculus) exposed to lead acetate.
Keywords:
Red galangal extract; Lead acetate; Pneumocyte type I; Pneumocyte type II; Healthcare
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