Antimicrobial guanidine alkaloids from the leaves of Crotalaria bernieri Baill. (Fabaceae)

Herizo Lalaina Andriamampianina 1, *, Danielle Aurore Doll Rakoto 1, Hanitra Ranjàna Randrianarivo 1, Alain Blond 2, Victor Louis Jeannoda 1 and Bernard Bodo 2

1 Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar.
2 FRE 3206 CNRS-MNHN, Molecules of Communication and Adaptation of Micro-organisms, National Museum of Natural History, 63 rue Buffon, 75005 Paris, France.
 
Research Article
GSC Biological and Pharmaceutical Sciences, 2024, 29(03), 027–037.
Article DOI: 10.30574/gscbps.2024.29.3.0456
Publication history: 
Received on 07 October 2024; revised on 04 December 2024; accepted on 06 December 2024
 
Abstract: 
A new guanidine alkaloid cyclocrotalarin together with sphaerophysin and 2''-O-α-rhamnoside vitexin have been isolated from the leaves of Crotalaria bernieri a Fabaceae. The structures were elucidated by spectroscopic methods including MS, 1D and 2D NMR and their antimicrobial activity examined.
 
Keywords: 
Crotalaria; Guanidine alkaloids; Flavonoids; Fabaceae
 
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