Biochemical study on immunomodulation and safety margin of inosine acedoben dimepranol before and after vaccination
Department of Biochemistry, Benha University, Egypt.
Research Article
GSC Advanced Research and Reviews, 2019, 01(01), 017-025.
Article DOI: 10.30574/gscarr.2019.1.1.0008
Publication history:
Received on 14 October 2019; revised on 09 November 2019; accepted on 13 November 2019
Abstract:
The aim of this study was to evaluate the immunopotentiating effect of IAD in broiler chickens either vaccinated or unvaccinated and to evaluate the safety profile of IAD after treatment with escalating doses. To assess the immunological effect of IAD, eighty chicks were used and divided into four groups. First group kept as control group, second received Isoprinosine (16.3 mg/kg, day after day), third received a routine New Castle disease virus vaccine and the last group received both treatments of Isoprinosine and ND vaccine. The second part of the study aimed to evaluate the safety profile of IAD, to achieve this aim eighty chicks were used, divided equally and given different concentration of IAD 8.15, 16.3, 32.6 mg/kg day after day repetitively. We concluded that, IAD enhanced both nonspecific and specific immune responses in broiler chicken, especially in vaccinated ones, in terms of increased antibody and decreased NDV titers, indicated by HI and PCR, respectively. Also, IAD showed dose-dependent good safety profile, including blood picture, organ function profile and metabolic parameters, indicated by biochemical analyses.
Keywords:
IAD; ND vaccine; Safety Profile
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Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
