Clinicopathological characteristics of osteosarcoma cases in a tertiary referral hospital in Indonesia: A 5-year retrospective study
1 Department of Anatomical Pathology, Faculty of Medicine Universitas Brawijaya - Saiful Anwar General Hospital, Indonesia.
2 Department of Biomedical Sciences, Faculty of Medicine Universitas Brawijaya, Indonesia.
3 Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Brawijaya - Saiful Anwar General Hospital, Indonesia.
Research Article
GSC Advanced Research and Reviews, 2024, 18(02), 009–016.
Article DOI: 10.30574/gscarr.2024.18.2.0038
Publication history:
Received on 13 December 2023; revised on 31 January 2024; accepted on 02 February 2024
Abstract:
Introduction: Osteosarcoma is the most common primary non-hematopoietic malignant bone tumor, which reportedly has a high incidence in several regions of the world including South-east Asia. However in Indonesia, the data regarding osteosarcoma trends and clinicopathological features are still lacking. Therefore, this paper aims to describe the clinicopathological features of osteosarcoma cases in a tertiary referral hospital in Indonesia.
Methods: A retrospective study of osteosarcoma cases at the Department of Anatomic Pathology of a tertiary referral hospital in East Java was conducted. Clinicopathological data regarding osteosarcoma cases diagnosed within a 5-year period (January 2018 - December 2022) were obtained. Statistical analysis were performed to the collected data.
Results: A total of 44 cases were found, with a male predominance (65.9%) and in the younger age group (11-20 years old, 36.4%). Most of osteosarcoma cases occurred in femur (50%). High grade cases predominated our cohort, with osteoblastic osteosarcoma being the most prevalent histological type (52.3%).
Conclusion: Male patients especially in younger age group predominated the cases in our center. Femur is the most common site for osteosarcoma, and most cases of osteosarcoma were of high-grade type. Osteoblastic osteosarcoma is the most common histological diagnosis in our cohort. Future larger-scale studies and nation-wide registry in order to provide better understanding and formulate the best approach for patient management are warranted.
Keywords:
Osteosarcoma; Clinicopathological Features; Epidemiology; Trends; Indonesia
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
