Early evolution of biochemical markers in severe and non-severe patients infected with Covid-19

Taoufik Ben Houmich 1, *, Mehdi Aouati 1, Hamza Oualhadj 1, Hassan Qacif 2, 5, Rachid Seddiki 3, 5, Younes Aissaoui 3, 5, Zakaria Chahbi 4, 5, Abderrahman Boukhira 1, 5 and Saliha Chellak 1, 5

1 Department of Biochemistry-Toxicology, Avicenna military hospital of Marrakech, Morocco.
2 Department of Internal Medicine, Avicenna military hospital of Marrakech, Morocco.
3 Department of Anesthesiology and Reanimation, Avicenna military hospital of Marrakech, Morocco.
4 Department of infectious diseases, Avicenna military hospital of Marrakech, Morocco.
5 Faculty of medicine and pharmacy of Marrakesh, Morocco.
 
Research Article
GSC Advanced Research and Reviews, 2022, 11(01), 193–198.
Article DOI: 10.30574/gscarr.2022.11.1.0107
Publication history: 
Received on 07 March 2022; revised on 19 April 2022; accepted on 21 April 2022
 
Abstract: 
Coronavirus disease 2019 (COVID-19) is an emerging infection that has caused a pandemic, it is due to a virus of the coronavirus family called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which can evolve into severe forms leading to death. Several biochemical alterations have been described in COVID-19 patients with great significance for clinical diagnosis and outcome prediction. The aim of this study is to compare early evolution of biochemical disturbances in COVID-19 patients and correlate them to severity of the disease.
This study was conducted in 70 COVID-19 patients hospitalized at the Avicenna military hospital. 20 patients in the medical intensive care unit (severe group) and 50 patients in the COVID-19 isolation hospital (non-severe group).
Across our laboratory data analysis of the two groups of COVID-19 patients, we demonstrated that high titles and early elevation of ferretinemia, Interleukin-6, High-Sensitivity Troponin T(us), NT-Pro-BNP, Blood Urea nitrogen, Creatinine and LDH are significantly correlated to severity of the disease.
The analysis of this study through the recent scientific literature demonstrates the interest of early monitoring of biochemical markers in the diagnosis of severity and monitoring of severe forms of covid-19.
 
Keywords: 
COVID-19; Early evolution; Laboratory data; Biochemical disturbances; Severity
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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