Effect of alpha-cypermethrin on serotonin, nor-epinephrine and brain changes in rats
1 Dept. of Veterinary Hygiene and Environmental Pollution, Faculty of Veterinary Medicine, Cairo University, Egypt.
2 Researcher in Dept. of Pharmaceuticals Biotechnology, Martin Luther King College, Germany. Email.
3 Researcher in Dept. of Hygiene and Environmental Pollution, Faculty of Veterinary Medicine, Cairo University, Egypt.
Research Article
GSC Advanced Research and Reviews, 2020, 04(01), 069-077.
Article DOI: 10.30574/gscarr.2020.4.1.0060
Publication history:
Received on 13 July 2020; revised on 29 July 2020; accepted on 30 July 2020
Abstract:
In the present study, brain damages, serotonin and nor-epinephrine activity on rat brain were investigated. A single sub-acute lethal -oral dose of Alpha-Cypermethrin (25 mg kg -1) was given to rat. Blood and brain tissue samples were examined biologically and histopathologically at various times (1, 2, 3, 4 and24 h) after dosing. Results revealed that extracellular serotonin levels % (f mol/mg tissue) in rat ventral hippocampus at 25 mg kg-1 B.W. After 1, 2, 3 and 24 hr. were 105±4, 80 ±7, 80 ±4, 70 ±4, respectively. While extracellular NA levels after 1, 2, 3 and 24 hr. were 300±10, 450 ±14, 400±12, 400±11, respectively. Alpha-cypermethrin acts as nor-epinephrine reuptake inhibitors (NRIs) and serotonin reuptake stimulator in rat brain. The lesions in the brain of the treated groups were gliosis, perineuronal vacuolation, perivascular vacuolation, and neuronal degeneration.
Keywords:
Brain Damage; Alpha-Cypermethrin; Acute Sub-Lethal Dose; Serotonin; Nor-epinephrine.
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
