The aim of this study was to evaluate the analytical performance of the two new CS-2500 automated systems recently acquired by the laboratory. These are Sysmex automated systems that perform multiparametric haemostasis tests based on coagulometric, chromogenic and immunological principles with an optical detection system. The aim of this study was to evaluate their performance for prothrombin time (PT) and activated partial thromboplastin time (APTT) tests. Comparability results with the CS-2100 department's previous automated system showed high agreement between the systems, with high correlation coefficients (R ≥ 0.993). Intra-series and inter-series repeatability was less than 5%, demonstrating excellent measurement stability. The search for inter-sample contamination was negative. The automated systems showed excellent linearity over a wide range of values. All the results obtained during this evaluation point to very good analytical performance, making the CS-2500 suitable for medium- to high-activity haemostasis laboratories.