Findings in magnetic resonance spectroscopy in patients with Autism spectrum disorder

Isaac Tenório 1, Lara Brandão 2, Aderbal Sabrá Filho 3, Selma Sabrá 4, Thiago Luiz Bandeira 5, Isabela Mansur Bandeira 5, Ana Maria E. Dias dos Santos 5, Nilse Andréia Marcos Manuel 5, Paula Pessanha Silva Mitre 5, Camila Marques Rebello 5, Bruno de Brito Braga 5, Luiz Werber Bandeira 5 and Aderbal Sabra 1, *

1 Unit of Food Allergy and Autism, Holy House of Mercy of Rio de Janeiro, RJ, Brazil
2 Luiz Felippe Mattoso Radiological Clinic, Rio de Janeiro, RJ, Brazil
3 University of the Grand Rio, School of Medicine, Duque de Caxias - Rio de Janeiro, RJ, Brazil
4 Pediatric Endoscopy Service, Antonio Pedro University Hospital, Fluminense Federal University, Niterói - Rio de Janeiro, RJ, Brazil.
Clinical and Experimental Immunology and Allergy Service, Holy House of Mercy of Rio de Janeiro/IMUNODERM Clinic, Rio de Janeiro, RJ, Brazil.
 

 

Research Article
GSC Advanced Research and Reviews, 2023, 17(03), 066–072.
Article DOI: 10.30574/gscarr.2023.17.3.0453
Publication history: 
Received on 23 October 2023; revised on 06 December 2023; accepted on 09 December 2023
 
Abstract: 
Background: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition that has been the subject of extensive research, including studies using magnetic resonance imaging (MRI) to explore brain metabolites as potential biomarkers.
Methods: The objective of our study was to identify brain metabolites using magnetic resonance and proton spectroscopy that could serve as potential markers of ASD (Autism Spectrum Disorder).
Results: Magnetic resonance imaging did not reveal any brain morphological changes in ASD patients. However, the patients with ASD exhibited an elevated glutamate peak in 100% of cases.
Conclusions: Magnetic resonance imaging combined with cerebellar spectroscopy is an emerging tool for the diagnosis and management of autism. This approach shows promise in enhancing both the diagnosis and treatment of ASD.
 
Keywords: 
Magnetic resonance of the brain in ASD; Proton spectroscopy of the brain in ASD; Elevation of glutamate in the brain of ASD; Cerebellar spectroscopy of the brain in ASD
 
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Copyright information: 
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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