Haematological and biochemical studies on Justicia secunda infusion used in treatment of anaemia
Department of Biochemistry, Federal University of Technology, Owerri Nigeria, PMB 1526, Owerri, Nigeria.
Research Article
GSC Advanced Research and Reviews, 2024, 20(02), 057–068.
Article DOI: 10.30574/gscarr.2024.20.2.0286
Publication history:
Received on 23 June 2024; revised on 04 August 2024; accepted on 07 August 2024
Abstract:
The effect of ethanolic and infusion of Justicia secunda leaves in the animal organs was investigated using standard analytical protocols. A total of 40 albino rats divided into four groups of five rats each comprising one normal groups and three groups treated with 125, 250 and 500mg/kg body weight respectively. The infusion of J. secunda leaves was prepared using conventional methods. The hematological, biochemical and histological studies were also carried out as reported in previous literatures. The findings confirmed that Justicia secunda leaves are not toxic at the doses administered, there were significant concentrations of essential minerals such as sodium, potassium, calcium, iron, phosphorus, and sulfur. The hematological study conducted on the infusion of the leaves revealed several positive effects on blood parameters in experimental rats. The extract significantly P<0.05 elevated hemoglobin and platelet count, particularly at higher doses, compared to the control group. The liver function tests showed no significant alterations in AST, ALT, TP, and ALB levels; however, the infusion resulted in some alterations in ALP activity and total bilirubin concentration. The histopathological examination of liver tissues showed mild congestion and degenerative changes in higher dose groups, indicating potential dose-dependent hepatomegaly and stress on hepatic architecture.
Keywords:
Justicia secunda; Acute toxicity; Hematological study; Liver function parameter; Histopathological examination
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