The impact of diabetes on spermatogenesis
1 Faculty of Medicine and Nutrition, Universidad Juárez del Estado de Durango, Durango México.
2 Department of genetics, Faculty of Medicine and Nutrition, Universidad Juárez del Estado de Durango, Durango México.
Review Article
GSC Advanced Research and Reviews, 2024, 21(03), 040–046.
Article DOI: 10.30574/gscarr.2024.21.3.0462
Publication history:
Received on 17 October 2024; revised on 29 November 2024; accepted on 02 December 2024
Abstract:
Diabetes mellitus, a chronic metabolic disease characterized by persistent hyperglycemia, has been shown to have a significant impact on several body systems, including the male reproductive system, spermatogenesis, the process of sperm formation and development in the testes, can be adversely affected by the direct and indirect effects of diabetes, the main mechanisms involving oxidative damage, hormonal alterations, mitochondrial dysfunction and endoplasmic stress, The main mechanisms involve oxidative damage, hormonal alterations, mitochondrial dysfunction and endoplasmic stress, which can lead to a reduction in the quality and quantity of spermatozoa, as well as in their motility and morphology. In addition, diabetes can induce chronic inflammation and affect the integrity of the blood-testicular barrier, which alters the microenvironment necessary for healthy spermatogenesis, in the present communication we describe the theoretical aspects of the effects of diabetes on seminal fluid with emphasis on spermatogenesis as well as its impact on male fertility.
Keywords:
Diabetes mellitus; Spermatogenesis; Male fertility; Alterations to DNA
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
