A kinetic and mechanistic study of oxidation of N-Acetyl-DL-Methionine by pyridinium chlorochromate in aqueous DMF medium
Department of Chemistry, Govt. P. G. College Pratapgarh, 312605, Rajasthan, India.
Research Article
GSC Advanced Research and Reviews, 2024, 20(01), 484–494.
Article DOI: 10.30574/gscarr.2024.20.1.0311
Publication history:
Received on 23 June 2024; revised on 25 July 2024; accepted on 28 July 2024
Abstract:
The Kinetics of Oxidative transformation of N-Acetyl-DL-Methionine by pyridinium chlorochromate in aqueous DMF medium, containing perchloric acid has been studied at 40 ℃. The rate of reaction was found to be of first order dependence on PCC, N-Acetyl-DL-Methionine, and H+ ion Concentration. Michaelis–Menten type kinetics is observed respect to substrate. The increase in the rate of reaction with increase in acidity indicates the involvement of a protonated chromium(VI) species in the rate-determining step. The product of oxidation has been identified as N-Acetyl-DL-Methionine sulfoxide. The rate of reaction increased with increase in dielectric constant of the reaction medium. The activation parameters have been evaluated. On the basis of the experimental findings, a suitable mechanism and rate law has been proposed.
Keywords:
Kinetics; Oxidation; DMF (N; N-dimethylformamide); N-Acetyl-DL-Methionine; PCC (pyridinium chlorochromate)
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