The mechanistic modes of Targeting immunometabolism in cancer: An innovative strategy: A narrative review
1 Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar-144001, Punjab, India.
2 Ex-Rotunda-A Centre for Human Reproduction. 672, Kalpak Garden, Perry Cross Road, Near Otter’s Club, Bandra(W)-400040, Mumbai, India.
Review Article
GSC Advanced Research and Reviews, 2024, 20(01), 005–024.
Article DOI: 10.30574/gscarr.2024.20.1.0233
Publication history:
Received on 14 May 2024; revised on 28 June 2024; accepted on 01 July 2024
Abstract:
Previously we had detailed different gynaecological cancers, inclusive of high grade serous ovarian cancers(HGSOC),breast cancer(BC), Hepatocellular carcinoma(HCC), non small lung cancer (NSCLC),bile acids in cancer,colorectal cancer with etiopathogenesis, treatment yet 5 year survival is substantially poor. Additionally, considering a considerable association of obesity with escalating incidence of cancers recently the concept of immunometabolism for targeting cancers has emerged. Furthermore,we had detailed alterations in metabolism in depth including macrophage polarization, SIRT signaling pathway,in T2DM, targeting PI3K/ PTEN/ AKT signaling pathwaysin germ cell tumors and oocyte generation, MAPK/ERK andHippo/MST signaling for cancers, PD1/ PDL1 (programmed death1)/ (programmed death ligand1 pathways in ovarian cancers /&tecemotide therapy for NSCLC, PI3K/ AKT/mTOR signaling in T2DM treatment and autophagy role . With advancements of immunometabolic scientific research advantages of using innovative strategies is got for immune controlling . Propagative metabolic adaptation of tumor cells aids in generation of a fluorishing tumor microenvironment(TME),where immune cells get their capability of earlier killing totally eliminated all the time persists an unresolved conundrum despite the generation of immune checkpoints treatments. In current decade numerous studies on tumor immunometabolism have been displayed. Generating immunometabolism might promote formation of antitumor immunotherapies from the continuos crosstalk amongst metabolism and immunity. Here our concentration is over the crucial targets of every key signaling pathways,ii) the molecule existent in upstream as well as downstream signaling along with cell demise modulated by them and immunometabolic checkpoints that have been displayed to possess significant controlling part are further described.Thus the idea of this is provision of necessary knowledge regarding molecular signaling in immunometabolism context and targeting approaches in oncology research and emphasizes the manner this area guides advancements in treatment of tumors.
Keywords:
Immunometabolism; PI3K/ AKT/mTOR; LKB-AMPK pathway; Immune checkpoints; Tumor microenvironment( TME)
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