Naja nubiae venom ameliorate hepatorenal toxicity induced by Gentamicin in rats
1 Zoology Department - Faculty of Science - Cairo University, Giza, Egypt.
2 Department of zoology, Faculty of arts and sciences Alabyar, University of Benghazi, Libya.
Research Article
GSC Advanced Research and Reviews, 2021, 09(03), 030–038.
Article DOI: 10.30574/gscarr.2021.9.3.0290
Publication history:
Received on 30 October 2021; revised on 03 December 2021; accepted on 05 December 2021
Abstract:
Background: In developing countries, there is no doubt that acute kidney injury and chronic liver diseases have a major impact on health. Different venom components are gaining renewed interest as potential sources of new pharmacological compounds relevant for human therapeutics.
Aim: The present study was designed to evaluate the therapeutic efficacy of the crude venom extract of the Egyptian spitting cobra (Naja nubiae) venom extract against gentamycin–induced nephrotoxicity and hepatotoxicity in rats. Methods: Eighteen male Wistar rats were divided into three groups, control, gentamycin, and venom extract. The hepatorenal toxicity model was induced by gentamycin (80 mg/kg, intraperitoneal) for 8 days.
Results: LD50 of venom extract in rats was 0.2mg/kg. The venom extract group showed a significant decrease in the liver enzymes, urea, uric acid, creatinine, malondialdehyde meanwhile glutathione reduced and catalase levels increased. Histological examination of liver and kidney mild protective efficacy with less extensive degenerative changes in the tissues of venom extract grou
Conclusion: The results of the present investigation showed that administration of venom extract proved therapeutic efficacy against gentamycin -induced hepatorenal dysfunction by maintain the normal functional status of the liver and kidney and normalized the antioxidant system.
Keywords:
Naja nubiae; Spitting cobra; Hepatorenal toxicity; Gentamycin; Venom
Full text article in PDF:
Copyright information:
Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
