Non-invasive exosome diagnostics for Parkinson's disease
Department of Genetics, Faculty of Medicine and Nutrition. Universidad Juárez del Estado de Durango., Durango, Dgo., México.
Research Article
GSC Advanced Research and Reviews, 2024, 21(03), 198–204.
Article DOI: 10.30574/gscarr.2024.21.3.0474
Publication history:
Received on 22 October 2024; revised on 02 December 2024; accepted on 05 December 2024
Abstract:
Parkinson's disease (PD) is a neurodegenerative disease, characterized by signs and symptoms such as festinating gait, bradykinesia, resting tremor, and cognitive delays.
Exosomes have emerged as biomarkers of clinical interest for the diagnosis and prevention of Parkinson's disease. These organelles between 30 nm and 200 nm in diameter play a crucial role in protein biogenesis, cellular homeostasis, and cell-to-cell signal transmission.
Exosomes with intraneuronal accumulation of α-synuclein protein are relevant in Parkinson's disease as a key pathological feature in disease progression and Lewy body formation.
Keywords:
Exosome; a-Synuclein; Parkinson's disease; Lewy bodies; Extracellular vesicles; Basal ganglia
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
