Protective and curative mechanisms of echinochrome against 7, 12-Dimethylbenz[a]anthracene -induced renal toxicity in rats
1 M.Sc., Biotechnology, Chemistry department, Faculty of Science, Cairo University, Egypt.
2 Lecturer of Physiology, Zoology Department, Faculty of Science, Cairo University, 12613, Giza, Egypt.
3 Prof. of Molecular Physiology and Biotechnology, Zoology Department, Faculty of Sciences, Cairo University, Egypt.
4 Prof. of Inorganic Chemistry, Chemistry Department, Faculty of Sciences, Cairo University, Egypt.
Research Article
GSC Advanced Research and Reviews, 2021, 06(01), 047-055.
Article DOI: 10.30574/gscarr.2021.6.1.0007
Publication history:
Received on 09 January 2021; revised on 16 January 2021; accepted on 19 January 2021
Abstract:
Echinochrome (Ech) is one of the most important bioactive substance which is found in shells, spines, and eggs of the sea urchins. Aim: the present study was carried out to evaluate the curative and protective effects of Ech pigment against DMBA -induced renal toxicity in rats. Methods: Experimental rats were assigned into two main groups; protective group (treated with Ech for 14 days then administrated DMBA) and curative group (administrated DMBA then treated with Ech for 14 days). Each group is divided into 3 sub-groups; control, DMBA (15 mg/ kg body, weight orally), and Ech (1 mg/ kg body, weight orally). Results: The oral administration of Ech decreased the concentrations of urea, creatinine, uric acid, and MDA and increased GSH and CAT levels in both protective and curative groups. Moreover, histology of kidney tissue improved after the treatment with Ech. Conclusions: The results of the present study demonstrated the potential protective and curative activities of Ech against renal toxicity induced by DMBA through inhibiting the metabolism of DMBA and restoring the balance between ROS formation and internal antioxidant enzymes by its powerful antioxidant activity.
Keywords:
Echinochrome; Renal toxicity; DMBA; Antioxidant; Sea urchin
Full text article in PDF:
Copyright information:
Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
