Recurrent Pneumocystis jirovecii pneumonia in an HIV-infected patient: A case report

Nina Dimitrova Tsvetkova 1, Rumen Nenkov Harizanov 1, *, Aleksandra Ivanova Ivanova 1, Dimitar Todorov Strashimirov 2, Rusina Stanislavova Grozdeva 2 and Nina Stoyanova Yancheva-Petrova 3

1 National Centre of Infectious and Parasitic Diseases, Department of Parasitology and Tropical Medicine, Sofia, 1504, Bulgaria.
2 Specialized Hospital for Active Treatment of Infectious and Parasitic Diseases (SHATIPD, Department for AIDS, Sofia, 1431, Bulgaria.
3 Medical University-Sofia, Department for Infectious Diseases, Parasitology and Tropical Diseases, Sofia, 1431, Bulgaria.
 
Case Study
GSC Advanced Research and Reviews, 2021, 07(02), 083–086.
Article DOI: 10.30574/gscarr.2021.7.2.0104
Publication history: 
Received on 07 April 2021; revised on 11 May 2021; accepted on 14 May 2021
 
Abstract: 
We present a case of Pneumocystis pneumonia (diagnosis was based on imaging X-ray and CAT examinations, and real-time PCR) in an HIV-infected patient with relapse four months later and long lasting colonization as detected by the positive real-time PCR results and lack of clinical symptoms during the follow up of the patient after second course of treatment with trimethoprim/sulfamethoxazole. The wild-type P. jirovecii DHPS genotype was identified in all patient samples tested.
 
Keywords: 
Pneumocystis jirovecii; Pneumocystis pneumonia (PCP); Real-time PCR; Colonization
 
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