Review on molecular designing of polymeric carriers use in gene therapy for diabetes
1 Bachelor of Pharmacy, Shraddha Institute of pharmacy, Washim, Maharashtra, India.
2 Bachelor of pharmacy, Shraddha Institute of pharmacy, Washim, Maharashtra, India.
3 Department of Industrial pharmacy, Shraddha Institute of pharmacy, Washim, Maharashtra, India.
4 Department of pharmacology, Shraddha Institute of pharmacy, Washim, Maharashtra, India.
Review Article
GSC Advanced Research and Reviews, 2024, 21(03), 316-323.
Article DOI: 10.30574/gscarr.2024.21.3.0385
Publication history:
Received on 11 September 2024; revised on 11 December 2024; accepted on 13 December 2024
Abstract:
Gene therapy holds promise for treating diabetes by addressing its root causes at the molecular level. A key factor in its success is the development of effective delivery systems, with polymeric carriers emerging as versatile vehicles. This review highlights the molecular design of polymeric carriers for diabetes gene therapy, focusing on critical parameters like polymer structure, size, charge, and surface modification that influence gene encapsulation and release.
Biodegradable polymers such as PLGA, chitosan, and PEI are emphasized for their ability to protect therapeutic genes and enable controlled release. In diabetes, these carriers aim to deliver genes that modulate insulin production, enhance β-cell regeneration, or prevent immune-mediated destruction. The review also explores stimulus-responsive polymers that offer on-demand release based on glucose levels.
Recent preclinical and clinical studies are discussed, addressing challenges and strategies for optimizing polymeric carriers. These molecular design insights could pave the way for safer, more efficient gene delivery systems in diabetes treatment.
This abstract emphasizes the design principles, challenges, and emerging strategies in polymeric carrier systems for gene therapy in diabetes.
Keywords:
Gene therapy; Role of gene therapy in diabetes; Polymeric Carriers; Recent advancement; Application; Advantages; Disadvantages
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
