Structure, mutations and variants of Coronavirus 2 (SARS-CoV): A brief report
¹ Prince Sultan Military Medical City, Division of Neonatology, Department of Pediatrics, Saudi Arabia.
2 Department of Research, King Saud Bin Abdulaziz University for Health Sciences, National Guards, Saudi Arabia.
Review Article
GSC Advanced Research and Reviews, 2022, 10(03), 001–006.
Article DOI: 10.30574/gscarr.2022.10.3.0050
Publication history:
Received on 06 January 2022; revised on 27 February 2022; accepted on 01 March 2022
Abstract:
The COVID-19, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome SARS-CoV-2. The novel virus was first identified from an outbreak in the Chinese city of Wuhan in December 2019, and attempts to contain it there failed, allowing it to spread across the globe. The ongoing pandemic is resulting from extreme acute breathing syndrome. The World Health Organization declared a Public Health Emergency of International Concern on 30 January 2020 and later declared a pandemic on eleven March 2020. As of eight July 2021, greater than 185 million instances had been showed, with greater than four million deaths attributed to COVID-19. Over two hundred twenty-eight million cases of COVID-19 in the world have been reported until the 21st of September 2021 after the first rise in December 2019. The virus caused the disease called severe acute respiratory syndrome. The structure of SARC-CoV-2 shows the presence of Spike S protein, Membrane M protein, Envelop protein and Nucleocapsid. Currently, four SARS-CoV-2 variants, these are Alpha, Beta, Gamma, Delta and Omicron variants originated from United Kingdom, South Africa, Brazil/Japan, and India, respectively. The classification of SARS-CoV-2 variants is based on the mutations in the structure, based inclusions. Mutations in covid-2 create variants which are helpful in making stable vaccine and/or anti-viral drug design. In view of the significance of the structure, mutations and variants of Covid-19, it was found necessary to emphasize the whole problem into a brief review.
Keywords:
SARS-CoV-2 genomes; 149 mutations; Variants – Alpha; Beta; Gamma; Delta and Omicron; Stable vaccine or anti-viral drug design
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
