Teratoma induced by amlodipine drug in fetus rats
1 Department of Biology, College of Education for Pure science, Thi-Qar University, Iraq.
2 Collage of Education for pure science, Thi-Qar University, Iraq.
3 College of Education for Pure Sciences (Ibn Al-Haitham), University of Baghdad, Iraq.
Research Article
GSC Advanced Research and Reviews, 2023, 16(02), 166–171.
Article DOI: 10.30574/gscarr.2023.16.2.0340
Publication history:
Received on 12 July 2023; revised on 19 August 2023; accepted on 22 August 2023
Abstract:
The current study, performed during the period from February 2021 to June 2022 at the University of Thi- Qar/ College of Education for Pure Sciences, and aimed to follow the changes in external morphological features at different Embryonic developmental stages in pregnant rats treated with different doses of amlodipine. Usage In this study, 18 pregnant rats were randomly divided into three groups, each with six pregnant rats. Each group received different concentrations of amlodipine (0.3, 0.5) in oral doses until the 20th day of gestation, while the control group was injected with 0.9% normal saline.
Teratomas are bizarre tumors derived from embryonic tissue that are normally found only in the gonadal and sacral regions of adults. Primary retroperitoneal teratomas are rare and present challenging management options. In one outcome, a teratoma was found in one of the amlodipine-treated groups. Complete excision of the teratoma mass was performed.
Keywords:
Amlodipine; Teratoma; Hypertension; Pregnant rats
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
