Musculoskeletal stretch injury shows a faster recovery compared to contusion in rats

Rodrigo Pereira Martins 1, Diane Duarte Hartmann 2, Andrezza Bond Vieira Furtado 1, Debora Farina Gonçalves 1, Thayanara Cruz da Silva 1, Luis Ulisses Signori 3, Felix Alexandre Antunes Soares 1 and Gustavo Orione Puntel 4, *

1 Department of biochemistry and toxicology, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
2 Department life of science, Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUI), Ijuí, Rio Grande do Sul, Brazil.
3 Department of physiotherapy and rehabilitation, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
4 Department of morphology, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
 
Research Article
GSC Advanced Research and Reviews, 2022, 12(02), 001–014.
Article DOI: 10.30574/gscarr.2022.12.2.0205
Publication history: 
Received on 01 July 2022; revised on 04 August 2022; accepted on 06 August 2022
 
Abstract: 
Background: The musculoskeletal repair, in most cases, follows the typical inflammatory process. Although the majority of treatments result in good prognosis, the knowledge concerning basic biochemical principles, regeneration and repair mechanisms of skeletal muscles may help in recovery and accelerate the return to sport, helping to carefully choose the more appropriate therapeutic techniques for the injury management.
Objective: This study investigated the effects of contusion and stretch injury on the oxidative damage in the gastrocnemius muscle of rats.
Methods: The biochemical analysis was performed on the 1, 3, 5, or 7 days after the injuries and behavior analysis was performed until 48 hours after injuries to evaluate the healing process changing characteristics.
Design: Experimental animal study.
Results: The contusion and stretch injury increased the oxidative stress markers levels; however, the injuries showed significant differences from each other in the markers of oxidized dichlorofluorescein, superoxide dismutase enzyme activity and N-acetyl-beta-glucosaminidase enzyme activity in skeletal muscle tissue. Furthermore, the injuries showed differences in behavioral analyses in the beam walking test.
Conclusion: In conclusion, we could infer that the stretch injury presents an early increase in the activity of the N-acetyl-β-D-glucosaminidase enzyme, indicating a possible macrophage increase in the first hours after injury.
 
Keywords: 
Muscle injurie; Oxidative stress; Inflammatory; Contusion; Stretch injury
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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