Glutamine in the cerebellum by magnetic resonance for the diagnosis of Autism
1 Unit of Food Allergy and Autism, Holy House of Mercy of Rio de Janeiro, RJ, Brazil.
2 University of the Grand Rio, School of Medicine, Duque de Caxias - Rio de Janeiro, RJ, Brazil.
3 Pediatric Endoscopy Service, Antonio Pedro University Hospital, Fluminense Federal University, Niterói - Rio de Janeiro, RJ, Brazil.
4 Clinical and Experimental Immunology and Allergy Service, Holy House of Mercy of Rio de Janeiro/IMUNODERM Clinic, Rio de Janeiro, RJ, Brazil.
Research Article
GSC Advanced Research and Reviews, 2023, 14(02), 144–150.
Article DOI: 10.30574/gscarr.2023.14.2.0366
Publication history:
Received on 01 December 2022; revised on 13 February 2023; accepted on 15 February 2023
Abstract:
Background: Brain metabolites are involved in processes of excitation and cellular transmission and can provide the sites and indices of synaptic activity and plasticity in addition to supporting inferences about the ongoing pathophysiology. Among them, changes in glutamate levels are involved in the regulation of neurotransmitter activity and are responsible for several behavioral and electrophysiological phenotypes in autism including deficits in cognitive and motor behavior and social reward.
Objective: To study the changes in biochemical metabolites in the cerebellum by magnetic resonance spectroscopy (MRS) for diagnosis of autism.
Methods: One hundred patients with ASD, we randomly selected and submitted to imaging exams in their CNS by magnetic resonance with nuclear proton spectroscopy. All selected patients were examined by the same doctor and their imaging exams were performed by the same neuro-radiology professional.
Conclusions: Magnetic resonance imaging with cerebellar spectroscopy is a new tool for the diagnosis and management of autism and can serve all physicians, even if they are not specialists, as a guide for this difficult to manage condition. It can serve both as a means of diagnosis and as a clinical follow-up for the treatment of ASD.
Keywords:
Autism spectrum disorder; Magnetic resonance spectroscopy; Cerebellum; Diagnosis; Glutamine
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
