Assessment of growth arrest-specific 6 protein as a biomarker of glomerular damage in sickle cell anaemia
1 Department of Chemical Pathology, Faculty of Basic Clinical Sciences, Nnamdi Azikiwe University, PMB 5025, Nnewi; Anambra state, Nigeria.
2 Department of Chemical Pathology, College of Medicine, University of Ibadan; Oyo state Nigeria.
3 Department of Haematology, College of Medicine, University of Ibadan; Oyo state Nigeria.
4Department of Anatomic Pathology and Forensic Medicine, Faculty of Basic Clinical Sciences, Nnamdi Azikiwe University, Nnewi; Anambra state, Nigeria.
5 Department of Chemical Pathology, University College Hospital Ibadan; Oyo state Nigeria.
6 Epidemiology Unit, Department of Public Health, Ministry of Health, Ogun State, Nigeria.
Research Article
GSC Advanced Research and Reviews, 2023, 16(01), 036–045.
Article DOI: 10.30574/gscarr.2023.16.1.0297
Publication history:
Received on 21 May 2023; revised on 04 July 2023; accepted on 07 July 2023
Abstract:
Objective: To assess growth arrest-specific 6 (Gas6) protein as a biomarker of glomerular damage (glomerulopathy; nephropathy) in patients with sickle cell anaemia (SCA).
Methods: seventy SCA patients on routine clinic visit and seventy apparently healthy controls were recruited into the study and their blood and urine samples were collected while plasma Gas6 as well as urinary albumin and creatinine measured. Their socio-demographic and other anthropometric indices were documented. The study participants and controls were screened for urinary tract infection (UTI) using the urine dipstick combi-10 on their urine. The plasma Gas6 of all patients were compared with the albumin creatinine ratio (ACR) along with the ages. Albumin and creatinine levels were also compared with ages.
Results: Gas6 had an inverse though insignificant relationship with ACR and age in the patients; albumin, creatinine and albumin creatinine ratio varied directly with age in these patients.
Conclusion: Gas 6 was not found a useful marker of glomerulopathy in sickle cell anaemia.
Keywords:
Albumin; Creatinine; Albumin creatinine ratio; Gas6; Glomerulopathy; Sickle cell anaemia
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
