A review on amorphous solid dispersions for improving physical stability and dissolution: Role of polymers
1 Thermofisher Scientific Inc, Greenville, NC, USA, 27834.
2 Department of Pharmaceutics, Annamacharya college of pharmacy, Rajampet -516126, Annamayya Dist., Andhrapradesh, India.
3 Project and Alliance management Adaptive phage Therapeutics, Gaithersburg, MD, USA.
4 Department of Pharmaceutics, Annamacharya college of pharmacy, Rajampet -516126, Annamayya Dist., Andhrapradesh, India.
Review Article
GSC Advanced Research and Reviews, 2024, 19(03), 296–302.
Article DOI: 10.30574/gscarr.2024.19.3.0231
Publication history:
Received on 17 May 2024; revised on 24 June 2024; accepted on 26 June 2024
Abstract:
Amorphous solid dispersion (ASD) has been a successful strategy to improve solubility and dissolution rate of poorly soluble drugs. ASD improve the solubility and dissolution of drugs by existing as separate molecules in a polymer matrix. The stability of amorphous solid dispersions is dependent on thermodynamic, kinetic and environment factors. Thermodynamic factors include drug-polymer miscibility and solubility. Kinetic factors include glass transition temperatures, molecular mobility, drug-polymer interactions. Environment factors indirectly affect the stability of ASD by influencing the thermodynamic and kinetic factors. The focus of this review is to discuss the role of polymer in influencing the thermodynamic and kinetic stability of ASD.
Keywords:
Amorphous solid dispersion; Dissolution; Polymer matrix; Role of polymer; Bioavailability; Physical Stability
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