Pyrimidine derivatives: Recent discoveries and development towards its medicinal impact

SABIU RABILU ABDULLAHI *, ABUBAKAR MUHD SHAFI’I, SAPNA RAGHAV and MA’ARUF ABDULMUMIN MUHAMMAD

Department of Chemistry, Mewar University, Chittorghar, India.
 
Review Article
GSC Advanced Research and Reviews, 2024, 20(01), 114–128.
Article DOI: 10.30574/gscarr.2024.20.1.0248
Publication history: 
Received on 27 May 2024; revised on 08 July 2024; accepted on 11 July 2024
 
Abstract: 
Pyrimidine derivatives' many biological functions and possible therapeutic uses have attracted a lot of research in the field of medicinal chemistry. Recent developments in the synthesis, biological assessment, and therapeutic uses of molecules based on pyrimidines are highlighted in this review. The significance of pyrimidine derivatives in treating a range of ailments, including cancer, infectious diseases, and metabolic disorders, is discussed, along with innovative synthesis approaches and important pharmacological findings. In order to give a thorough picture of the present status of pyrimidine derivative research and its implications for upcoming medication development, this review will analyze recent literature and case studies.
 
Keywords: 
Pyrimidine; Anticancer Activities; Heterocyclic; Antimicrobial activity; Antitumor activity
 
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