Rare case of Chronic Myeloid Leukemia (chronic phase) in pediatric age group: Diagnostic and pathological perspective
1 American University of Barbados school of Medicine, Barbados.
2 Era’s Lucknow Medical College& Hospital, Era University, Lucknow, Uttar Pradesh, India.
Case Study
GSC Advanced Research and Reviews, 2024, 21(01), 034–036.
Article DOI: 10.30574/gscarr.2024.21.1.0343
Publication history:
Received on 10 August 2024; revised on 25 September 2024; accepted on 28 September 2024
Abstract:
Pediatric chronic myeloid leukemia is a rare childhood malignancy, accounting for 3-5% of all childhood cancers. Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (BCR-ABL1 fusion gene). While CML predominantly affects adults, pediatric cases are uncommon. This case report outlines the clinical presentation, diagnostic findings, and pathological features of CML in a 19-year-old female, who presented with marked leukocytosis, 61% basophilia, a myelocyte-metamyelocyte peak, and 2% blasts in the differential count. The leukocyte alkaline phosphatase score was reduced, and the p210 transcript of BCR-ABL1 was identified by polymerase chain reaction. Bone marrow was hypercellular with increased granulopoiesis and dysplastic megakaryocytes.
Keywords:
Chronic myeloid leukemia (CML); Pediatric; Philadelphia chromosome (Ph); Breakpoint cluster region-Abelson murine leukemia 1 gene (BCR-ABL1); Juvenile myelomonocytic leukemia
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