The impact of tobacco on spermatogenesis: Recent findings and reproductive outcomes

Gerardo Alfredo-Bermúdez 1, Andrea Paola-Castillo 1, Rodrigo-Diez 1, Kitzia Emily-Lucero 1, America Shaiel-Armas 1, *, Gloria Elizabeth-Zamora 1 and Brissia Lazalde 2

1 Faculty of Medicine and Nutrition UJED Av. Universidad zona centro and Fanny Anitúa s/n. C.P. 34000. Durango, Dgo., Mexico.
2 Department of genetics, Juárez University of the State of Durango., Durango, Dgo. México.
 
Review Article
GSC Advanced Research and Reviews, 2024, 21(02), 402–408.
Article DOI: 10.30574/gscarr.2024.21.2.0434
Publication history: 
Received on 06 October 2024; revised on 16 November 2024; accepted on 19 November 2024
 
Abstract: 
The use of tobacco is widespread among men and poses a significant concern for reproductive health. This review synthesizes recent evidence on the impact of cigarette smoking on spermatogenesis, emphasizing its effects on semen quality, reproductive hormone levels, metabolic profile, and sperm DNA fragmentation, which contribute to infertility.
Smoking is associated with increased oxidative stress and DNA fragmentation in sperm, both of which impair fertility outcomes. By examining these adverse effects, this review underscores the importance of addressing tobacco use in male populations to mitigate infertility risks. Insights into the mechanisms of action and broader public health implications are provided.
 
Keywords: 
Spermatogenesis; Psychoactive substance; Male infertility; Tobacco use; Reproduction.
 
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