Teratoma in Children: Three cases experience in Sanglah Hospital, Bali, Indonesia

Kusumadewi Riandra Ni Putu Indah; Ariawati Ketut; Anak Agung Ngurah  Ketut Putra Widnyana; Indrayani Maker Luh Putu Iin; Kusumawati I Gusti Ayu Ari

doi:10.30574/gscarr.2021.6.2.0014

Authors

Kusumadewi Riandra Ni Putu Indah Department of Child Health, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia.
Ariawati Ketut Department of Child Health, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia.
Anak Agung Ngurah Ketut Putra Widnyana Department of Child Health, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia.
Indrayani Maker Luh Putu Iin Department of Pathology-Anatomy, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia.
Kusumawati I Gusti Ayu Ari Department of Pathology-Anatomy, Klungkung Hospital, Klungkung, Indonesia.

DOI:

https://doi.org/10.30574/gscarr.2021.6.2.0014

Keywords:

immature teratoma, diagnosis, treatment, children

Abstract

Teratomas are the most common germ cell tumor, and further classified into mature or immature. Immature teratoma comprise less than one percent of all teratomas and with the peak incidence at birth until four years. They were diagnosed by history taking, physical examination, laboratory, imaging, and pathological anatomy as a gold standard. This report presents our experience of diagnosed, giving treatment with or without surgery and chemotherapy in three patients with teratoma. We report three cases of teratoma, at age six months, eight months and four years old with site of cases are retroperitoneal immature teratoma, cervical teratoma and ovarian immature teratoma. History taking of these patients, they have same symptom such as enlargement of the mass. Two cases were noticed after birth and progressively getting bigger until six and eight months old. One case was noticed when the patient had abdominal pain and was suspected with appendicitis at first. The computed tomography (CT) scan of these cases showed a mass as a part of teratoma and confirmed with pathological anatomy. Two cases were immature, and one case was mature teratoma. Two patients undergone surgery resection and continue with chemotherapy (cisplatin, etoposide, and bleomycin) for 10-14 weeks showed a good result until now and showed no residual mass anymore form CT scan, but one patient did not undergo surgery and chemotherapy yet. Early diagnosis of teratomas is leading us to a definitive therapy and showed a good result.

Metrics

Metrics Loading ...

References

Alotaibi Mohammed OS, Navarro Oscar M. Imaging of ovarian teratomas in children: A 9-year review. Carjoline. 2010; 61: 23-28.

Ayhan A, Bukulmez O, Genc C et al. Mature cystic teratomas of the ovary: case series from one instution over 34 years. Eur J Obstet Gynecol Reprod. Biol. 2000; 88: 153.

Shinkai Toko, Masumoto Kouji, Chiba Fumiko, Shirane Kazuki, Tanaka Yasunari, Aiyoshi Tsubasa, et al. Pediatric ovarian immature teratoma: Histological grading and clinical characteristics. Journal of Pediatrics. 2019; 1-4.

Strosberg J, Nasir A, Cragun J et al. Metastatic Carcinoid tumor to the ovary: A clinicopathologic analysis of seventeen cases. Gynecol Oncol. 2007; 106: 65.

Luczak Justyna, Baglaj Maciej. Ovarian teratoma in children: a plea for collaborative clinical study. Journal of Ovarian Research. 2018; 11: 75;1-8.

Huda Shehzad, Sangster Guillermo, Northcutt Ash;ey, Sorells Donald, Gates Thomas, Tice Hilary, Ibrahim Hasan. Retroperitoneal immature teratoma. J La State Med Soc. 2015; 167: 50-54.

Limaiem Faten, Sassi Asma, Bouraoui Saadia. Ovarian immature teratoma; repost of four cases. Journal of case reports in practice. 2016; 4(5): 50-53.

Li Junxia, Gong Peiyou, Liu Fengli, Sun Ping, Wu Chengrong. Retroperitoneal cystic immature teratoma: A case report. Oncology Letters. 2015; 10: 1023-1025.

Yang Tianyou, Li Huixian, Li Jiahao, Hu Chao, Tan Tianbao, yang Hiliang, Pan Jing, Zou Yan. Surgical Risk Factors of Retroperitoneal Teratoma Resection in Children. 2018; 18.

Chakravarti Arunabh, Shashidar TB, Naglot Shakuntala, Sahni JK. Head and Neck Teratomas in Children: A Case Series. Indian J Otolaryngol Head Neck Surg. 2011; 63(2): 193-197.

Sellami Moncef, Mnejja Malek, Ayadi Lobna, Charfeddine Ilhem, Boudawara Tahia, Hammami Boutheina, Ghorbel Abdelmonem. Congenital teratoma of the neck: A case report and literature review. Egyptian journal. 2014; 1-5.

Marina Kos, Nikic Jasmina, Lenicek Tanja. Ovarian teratoma in routine biopsy material during a five year period. Acta Clin Croat. 2016; 55(2): 265-270.

Catherine Jane Hunter, et al. Alpha-fetoprotein levels correlate with the pathologic grade and surgical outcomes of pediatric retroperitoneal teratomas. Pediatr Surg Int 2009; 25: 331-336.

Pashankar Farzana, Hale Juliet P, Dang Ha, Krallo Mark, Brady William E., Rodriguez-Galindo Carlos, et al., Is adjuvant chemotherapy indicated in ovarian immature teratoma? A combined data analysis from the malignant germ cell tumor international collaborative. Cancer. 2016; 122(2): 230-237.

Lopes Fernando Luiz, Macedo Pacheco Carla Renata, Pontes Elitania Marinho, et al. Cisplatin and Etoposide in Childhood Germ Cell Tumor: Brazilian Pediatric Oncology Society Protocol GCT-91. Journal of Clinical Oncology. 2009; 27(8): 1297-1303.

Dervishi Mario, Mohamad Aziz, Fonseca Carolina, Heidenreich Alicia. A giant immature teratoma of the ovary in 18-years old girl (a case report with uncommon presentation and review of the literature). Ann Clin Pathol. 2018; 6(3): 1139.

Mortazavi Nafiseh, Mahzooni Parvin, Taheri Diana, Jalilian Mahshid, Novin Kambiz. Germ Cell Tumor’s Survival Rate in Young Patients. Iran J Cancer Preven. 2015; 8(4).