Traumatic brain injury: Future application of nanomedicine

Authors

  • Nasima Khanam Department of Zoology, University Of Kalyani, Kalyani Nadia, West Bengal, India Pin 741235.
  • Debjani Nath Department of Zoology, University Of Kalyani, Kalyani Nadia, West Bengal, India Pin 741235.

DOI:

https://doi.org/10.30574/gscarr.2021.6.2.0019

Keywords:

Traumatic brain injury, Blast TBI, Pathophysiology, Blood brain barrier, Nanoparticle therapy

Abstract

Traumatic brain injury (TBI) is currently a rising player in the cause of disability and neurological dysfunction worldwide. TBI is a common occurrence in the military and extreme activities, sports arena and accidents. Severe TBI can be fatal but mild TBI persists and progressively deteriorates brain homeostasis and physiology. Apart from the physical disabilities, psychological complexities arise in people with mild TBI. Despite the seriousness of this hazard, treatments for TBI are not adequate, mostly due to the brain being involved. Nanoparticle (NP) therapy seems to be an effective alternative to combat TBI. This review outlines the state of TBI and describes the probable medical support that nanomedicine can provide.

Metrics

Metrics Loading ...

References

Prins M, Greco T, Alexander D, Giza CC. The pathophysiology of traumatic brain injury at a glance. Disease models & mechanisms. 2013; 6(6): 1307-15.

Sulhan S, Lyon KA, Shapiro LA, Huang JH. Neuroinflammation and blood–brain barrier disruption following traumatic brain injury: Pathophysiology and potential therapeutic targets. Journal of neuroscience research. 2020; 98(1): 19-28.

Miller SC, Whitehead CR, Otte CN, Wells TS, Webb TS, Gore RK, Maynard C. Risk for broad-spectrum neuropsychiatric disorders after mild traumatic brain injury in a cohort of US Air Force personnel. Occupational and environmental medicine. 2015; 72(8): 560-6.

Chapman JC, Diaz‐Arrastia R. Military traumatic brain injury: a review. Alzheimer's & Dementia. 2014; 10: S97-104.

Bryan CJ, Clemans TA. Repetitive traumatic brain injury, psychological symptoms, and suicide risk in a clinical sample of deployed military personnel. JAMA psychiatry. 2013; 70(7): 686-91.

Risdall JE, Menon DK. Traumatic brain injury. Philosophical Transactions of the Royal Society B: Biological Sciences. 2011; 366(1562): 241-50.

Marklund N. Blast-Induced Brain Injury. InManagement of Severe Traumatic Brain Injury. 2020; 109-113.

Evans V. Newton's laws, G-forces and the impact on the brain. Australasian Journal of Neuroscience. 2020; 30(1): 24.

Pearn ML, Niesman IR, Egawa J, Sawada A, Almenar-Queralt A, Shah SB, Duckworth JL, Head BP. Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics. Cellular and molecular neurobiology. 2017; 37(4): 571-85.

Zetterberg H, Smith DH, Blennow K. Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nature Reviews Neurology. 2013; 9(4): 201.

Wolf JA, Stys PK, Lusardi T, Meaney D, Smith DH. Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels. Journal of Neuroscience. 2001; 21(6): 1923-30.

Duckworth JL, Grimes J, Ling GS. Pathophysiology of battlefield associated traumatic brain injury. Pathophysiology. 2013; 20(1): 23-30.

Yoshino A, Hovda DA, Kawamata T, Katayama Y, Becker DP. Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper-and subsequent hypometabolic state. Brain research. 1991; 561(1): 106-19.

Winkler EA, Minter D, Yue JK, Manley GT. Cerebral edema in traumatic brain injury: pathophysiology and prospective therapeutic targets. Neurosurgery Clinics. 2016; 27(4): 473-88.

Hall ED, Vaishnav RA, Mustafa AG. Antioxidant therapies for traumatic brain injury. Neurotherapeutics. 2010; 7(1): 51-61.

Abdul-Muneer PM, Pfister BJ, Haorah J, Chandra N. Role of matrix metalloproteinases in the pathogenesis of traumatic brain injury. Molecular neurobiology. 2016; 53(9): 6106-23.

Xu L, Schaefer ML, Linville RM, Aggarwal A, Mbuguiro W, Wester BA, Koliatsos VE. Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding. Experimental neurology. 2016; 277: 268-74.

McGinn MJ, Povlishock JT. Pathophysiology of traumatic brain injury. Neurosurgery Clinics. 2016; 27(4): 397-407.

Moore J, Alzate‐Correa D, Dasgupta D, Lawrence W, Dodd D, Mathews C, Valerio I, Rink C, Higuita‐Castro N, Gallego‐Perez D. Micro‐and Nanoscale Biointerrogation and Modulation of Neural Tissue–From Fundamental to Clinical and Military Applications. Nanotechnology and Microfluidics. 2020: 383-417.

Sharma S, Ifergan I, Kurz JE, Linsenmeier RA, Xu D, Cooper JG, Miller SD, Kessler JA. Intravenous immunomodulatory nanoparticle treatment for traumatic brain injury. Annals of neurology. 2020; 87(3): 442-55.

Yokel RA. Nanoparticle brain delivery: a guide to verification methods. Nanomedicine. 2020; 15(04): 409-32.

Tosi G, Duskey JT, Kreuter J. Nanoparticles as carriers for drug delivery of macromolecules across the blood-brain barrier. Expert Opinion on Drug Delivery. 2020; 17(1): 23-32.

Sim TM, Tarini D, Dheen ST, Bay BH, Srinivasan DK. Nanoparticle-based technology approaches to the management of neurological disorders. International Journal of Molecular Sciences. 2020; 21(17): 6070.

Hubbard WB, Lashof-Sullivan M, Greenberg S, Norris C, Eck J, Lavik E, VandeVord P. Hemostatic nanoparticles increase survival, mitigate neuropathology and alleviate anxiety in a rodent blast trauma model. Scientific reports. 2018; 8(1): 1-2.

Bailey ZS, Nilson E, Bates JA, Oyalowo A, Hockey KS, Sajja VS, Thorpe C, Rogers H, Dunn B, Frey AS, Billings MJ. Cerium oxide nanoparticles improve outcome after in vitro and in vivo mild traumatic brain injury. Journal of Neurotrauma. 2020; 37(12): 1452-62.

Xu J, Ypma M, Chiarelli PA, Park J, Ellenbogen RG, Stayton PS, Mourad PD, Lee D, Convertine AJ, Kievit FM. Theranostic oxygen reactive polymers for treatment of traumatic brain injury. Advanced Functional Materials. 2016; 26(23): 4124-33.

Yoo D, Magsam AW, Kelly AM, Stayton PS, Kievit FM, Convertine AJ. Core-cross-Linked nanoparticles reduce neuroinflammation and improve outcome in a mouse model of traumatic brain injury. ACS nano. 2017; 11(9): 8600-11.

Clond MA, Lee BS, Jeffrey JY, Singer MB, Amano T, Lamb AW, Drazin D, Kateb B, Ley EJ, John SY. Reactive oxygen species-activated nanoprodrug of Ibuprofen for targeting traumatic brain injury in mice. PLoS One. 2013; 8(4): e61819.

Takahashi T, Marushima A, Nagasaki Y, Hirayama A, Muroi A, Puentes S, Mujagic A, Ishikawa E, Matsumura A. Novel neuroprotection using antioxidant nanoparticles in a mouse model of head trauma. Journal of Trauma and Acute Care Surgery. 2020; 88(5): 677-85.

Ruozi B, Belletti D, Sharma HS, Sharma A, Muresanu DF, Mössler H, Forni F, Vandelli MA, Tosi G. PLGA nanoparticles loaded cerebrolysin: studies on their preparation and investigation of the effect of storage and serum stability with reference to traumatic brain injury. Molecular neurobiology. 2015; 52(2): 899-912.

Khalin I, Alyautdin R, Wong TW, Gnanou J, Kocherga G, Kreuter J. Brain-derived neurotrophic factor delivered to the brain using poly (lactide-co-glycolide) nanoparticles improves neurological and cognitive outcome in mice with traumatic brain injury. Drug delivery. 2016; 23(9): 3520-8.

Kwon EJ, Skalak M, Lo Bu R, Bhatia SN. Neuron-targeted nanoparticle for siRNA delivery to traumatic brain injuries. ACS nano. 2016; 10(8): 7926-33.

Wang Y, Zhao P, Mao L, Hou Y, Li D. Determination of brain injury biomarkers by surface-enhanced Raman scattering using hollow gold nanospheres. RSC advances. 2018; 8(6): 3143-50.

Cruz LJ, Que I, Aswendt M, Chan A, Hoehn M, Löwik C. Targeted nanoparticles for the non-invasive detection of traumatic brain injury by optical imaging and fluorine magnetic resonance imaging. Nano Research. 2016; 9(5): 1276-89.

Ko J, Hemphill M, Yang Z, Sewell E, Na YJ, Sandsmark DK, Haber M, Fisher SA, Torre EA, Svane KC, Omelchenko A. Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles. Lab on a Chip. 2018; 18(23): 3617-30.

Bony BA, Kievit FM. A Role for Nanoparticles in Treating Traumatic Brain Injury. Pharmaceutics. 2019; 11(9): 473.

Downloads

Published

2021-02-28

How to Cite

Khanam, N., & Nath, D. (2021). Traumatic brain injury: Future application of nanomedicine. GSC Advanced Research and Reviews, 6(2), 020–027. https://doi.org/10.30574/gscarr.2021.6.2.0019

Issue

Section

Review Article