From hair colour to diagnosis

V. Broshtilova

doi:10.30574/gscarr.2021.7.2.0107

Authors

V. Broshtilova Department of Dermatology and Venereology, Military Medical Academy, Sofia, Bulgaria.

DOI:

https://doi.org/10.30574/gscarr.2021.7.2.0107

Keywords:

Follicular melanogenesis, Skin colour changes

Abstract

Hair pigmentation contributes extremely to the visual appearance and human-to-human communication, thus exerting enormous sexual and social impact. Follicular melanogenesis depends on genetic, biochemical and physical phenomena as well as proper epithelial-melanocytic interaction. Shades of grey, yellow, brown, red, and black produced by melanin define the exact determination of hair colour. Versatile clinical conditions depend on genetic melanogenetic changes, pigment transfer to bulb keratinocytes defects and impaired signal transduction pathways. Herein, an update of recent scientific advances on follicular melanogenesis and its pathological-driven compartmental changes reflecting specific disease phenotypes, are presented.

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References

Ancans J, Tobin DJ, Hoogduijn MJ, Smit NP, Wakamatsu K, Thody AJ. (2001). Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells. Exp Cell Res, 268, 26–35.

Arck PC, Overall R, Spatz K. (2006). Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J, 20, 1567–1569.

Commo S, Bernard BA. (2000). Melanocyte subpopulation turnover during the human hair cycle: An immunohistochemical study. Pigment Cell Res,13, 253–259.

Christoph T, Muller-Rover S, Audring H et al. (2000). The human hair follicle immune system: cellular composition and immune privilege. Br J Dermatol,142, 862–873.

Gilhar A, Landau M, Assy B, Shalaginov R. (2001). Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc (scid) mice. J Invest Dermatol, 117, 1357–1362.

He L, Eldridge AG, Jackson PK, Gunn TM. (2003). Accessory proteins for melanocortin signaling: Attractin and mahogunin. Ann N Y Acad Sci, 994, 288–298.

Costin GE, Valencia JC, Vieira WD, Lamoreux ML, Hearing VJ. (2003). Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (UW) mutation. A model for oculocutaneous albinism (OCA) type 4. J Cell Sci. 2003, 116, 3203–3212.

Dupin E, Le Douarin NM. (2003). Development of melanocyte precursors from the vertebrate neural crest. Oncogen, 22, 3016–3023.

Gillbro JM, Marles LK, Hibberts NA, Schallreuter KU. (2004) Autocrine catecholamine synthesis and the beta 2 adrenoceptor signal promote pigmentation in human epidermal melanocytes. J Invest Dermatol, 123, 346–353.

Hara M, Yaar M, Byers HR, Goukassian D, Fine RE, Gonsalves J, Gilchrest BA. (2000). Kinesin participates in melanosomal movement along melanocyte dendrites. J Invest Dermatol, 114, 438–443.

He L, Eldridge AG, Jackson PK, Gunn TM, Barsh GS. (2003). Accessory proteins for melanocortin signaling: Attractin and mahogunin. Ann NY Acad Sci, 994, 288–298.

Jimbow K, Park J, Kato F, Hirosaki K, Toyofuku K, Hua C, Yamashita T. (2000). Assembly, target-signaling and the intracellular transport of tyrosinase gene family proteins in the initial stages of melanosome biogenesis. Pigment Cell Res, 13, 222–229.

Kushimoto T, Valencia JC, Costin GE, et al. (2003). The melanosome: An ideal model to study cellular differentiation. Pigment Cell Res, 16, 237–244.

Marles LK, Peters EM, Tobin DJ, Hibberts NA, Schallreuter KU. (2003). Tyrosine hydroxylase isoenzyme I is present in human melanosomes: A possible novel function in pigmentation. Exp Dermatol, 12, 61–70.

Nakamura M, Tobin DJ, Richards-Smith B, Sundberg JP, Paus R. (2002). Mutant laboratory mice with abnormalities in pigmentation: Annotated tables. J Dermatol Sci, 28, 1–33.

Oyehaug L, Plante E, Vage DI, Omholt SW. (2002). The regulatory basis of melanogenic switching. J Theor Biol, 215, 449–468.

Slominski A, Paus R.(1993). Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invest Dermatol, 101, 90–97.

Stenn KS, Paus R. (2001). Controls of hair follicle cycling. Physiol Rev, 81, 449–494.

Slominski A, Wortsman J, Przemyslaw M, Schallreuter K, Paus R, Tobin D. (2005). Hair follicle pigmentation. J Invest Dermatol,124, 13-21.

Ito T, Ito N, Bettermann A, Tokura Y. (2004). Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. Am J Patholq 164, 623–634.

Lerner AB, Fitzpatrick TB. (1950). Biochemistry of melanin formation. Physiol Rev, 30, 91–126.