Distortion Product Otoacoustic Emissions (DPOAE) patterns in individuals with Type 1 and Type 2 Diabetes Mellitus - A comparative study

Madhavan  Balakrishnan; Jyothis  Kurian; Prem G  Nair

doi:10.30574/gscarr.2021.8.3.0183

Authors

Madhavan Balakrishnan Department of Audiology & Speech Language Pathology, AWH Special College, Kerala University of Health Sciences, Calicut, Kerala, INDIA.
Jyothis Kurian Department of Audiology & Speech Language Pathology, AWH Special College, Kerala University of Health Sciences, Calicut, Kerala, INDIA.
Prem G Nair College of Speech & Hearing, Mangalore Academy of professional studies, Mangalore University, Mangalore, Karnataka, INDIA.

DOI:

https://doi.org/10.30574/gscarr.2021.8.3.0183

Keywords:

Hearing Loss, Diabetes Mellitus, Otoacoustic Emission, Signal to Noise Ratio

Abstract

Diabetes mellitus (DM) is a chronic and potentially life-threatening condition, incidence of which is increasing rapidly in the present era. Various studies showed conflicting relationship between DM and Hearing Loss (HL). The current study was carried out to find the effect of Type 1 and Type 2 DM on hearing. The study group consisted of 90 adults in the age range of 20 to 40 years from various hospitals in and around Calicut, Kerala. These participants were divided into three groups: Group1 (Experimental group 1), included 30 individuals with Type 1 DM; Group 2 (Experimental group 2), included 30 individuals with Type 2 DM and Group 3 (Control group) included 30 age-matched non-diabetic individuals with normal hearing sensitivity. Results of the study revealed that there was significant difference in the DPOAE amplitude between Type 1 and Type 2 DM with control group and there was no significant difference in the DPOAE amplitude between Type 1 and Type 2 DM group. From the results it can be concluded that DPOAE amplitude were reduced in both Type 1 and Type 2 DM when compared to control group. This could be attributed to damage of the cochlear Outer Hair Cells (OHCs). Further, it could be assumed that damage to the OHCs due to DM in both Type 1 and Type 2 groups are relatively equal.

Metrics

Metrics Loading ...

References

Shoback. Greenspan's basic & clinical endocrinology (9th ed.). New York: McGraw-Hill Medical. Chapter. 2011; 17.

Sicree R, Shaw J, Zimmet P. Prevalence and projections. Diabetes atlas. 2006; 3: 16-04.

Lisowska G, Namyslowski G, Morawski K, Strojek K. Early identification of hearing impairment in patients with type 1 diabetes mellitus. Otology & neurotology. 1 May 2001; 22(3): 316-20.

Smith TL, Raynor E, Prazma J, Buenting JE, Pillsbury HC. Insulin‐dependent diabetic microangiopathy in the inner ear. The Laryngoscope. Mar 1995; 105(3): 236-40.

Rust KR, Prazma J, Triana RJ, Michaelis OE, Pillsbury HC. Inner ear damage secondary to diabetes mellitus: II. Changes in aging SHR/N-cp rats. Archives of Otolaryngology–Head & Neck Surgery. 1 Apr 1992; 118(4): 397-400.

Nakae S, Tachibana M. The cochlea of the spontaneously diabetic mouse. Archives of oto-rhino-laryngology. Nov Nov 1986; 243(5): 313-6.

Raynor E, Robison WG, Garrett CG, McGuirt WT, Pillsbury HC, Prazma J. Consumption of a high-galactose diet induces diabetic-like changes in the inner ear. Otolaryngology–Head and Neck Surgery. Dec 1995; 113(6): 748-54.

Ishikawa T, Naito Y, Taniguchi K. Hearing impairment in WBN/Kob rats with spontaneous diabetes mellitus. Diabetologia. 1995 Jun; 38(6): 649-55.

Makishima K, Tanaka K. Pathological changes of the inner ear and central auditory pathway in diabetics. Annals of Otology, Rhinology & Laryngology. Apr 1971; 80(2): 218-28.

Wackym PA, Linthicum Jr FH. Diabetes mellitus and hearing loss: clinical and histopathologic relationships. The American journal of otology. 1 May 1986; 7(3): 176-82.

Gates GA, Cobb JL, D'Agostino RB, Wolf PA. The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk factors. Archives of Otolaryngology–Head & Neck Surgery. 1 Feb 1993; 119(2): 156-61.

Dalton DS, Cruickshanks KJ, Klein R, Klein BE, Wiley TL. Association of NIDDM and hearing loss. Diabetes care. 1 Sep 1998; 21(9): 1540-4.

Okhovat SA, Moaddab MH, Okhovat SH, Al-Azab AA, Saleh FA, Oshaghi S, Abdeyazdan Z. Evaluation of hearing loss in juvenile insulin dependent patients with diabetes mellitus. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. Feb 2011; 16(2): 179.

Rózańska-Kudelska M, Chodynicki S, Kinalska I, Kowalska I. Hearing loss in patients with diabetes mellitus type II. Otolaryngologia polska= The Polish otolaryngology. 1 Jan 2002; 56(5): 607-10.

Díaz DL, Jáuregui-Renaud K, Garay-Sevilla ME, Hernández-Prado J, Malacara-Hernández JM. Auditory impairment in patients with type 2 diabetes mellitus. Archives of medical research. 2005; 36(5): 507.

Tay HL, Ray N, Ohri R, Frootko NJ. Diabetes mellitus and hearing loss. Clinical Otolaryngology & Allied Sciences. Apr 1995; 20(2): 130-4.

Salvinelli F, Miele A, Casale M, Greco F, D'Ascanio L, Firrisi L, Trivelli M, Petitti T, Aloe L, Pozzilli P. Hearing Thresholds In Patients With Diabetes.

Di Leo MA, Di Nardo W, Cercone S, Ciervo A, Monaco ML, Greco AV, et al. Cochlear dysfunction in IDDM patients with subclinical peripheral neuropathy. Diabetes care. 1 May 1997; 20(5): 824-8.

Cullen JR, Cinnamond M. Hearing loss in diabetics. The Journal of Laryngology & Otology. Mar 1993; 107(3): 179-82.

Ermshar CВ, Gay GС, Vanore J, House L. AUDIOMETRY CONFIGURATION AS A REFLECTION OF DIABETES. THE AMERICAN JOURNAL OF OTOLOGY. Jul 1988; 9(4).

Kurien M, Thomas K, Bhanu TS. Hearing threshold in patients with diabetes mellitus. The journal of laryngology & Otology. Feb 1989; 103(2): 164-8.

Fukushima H, Cureoglu S, Schachern PA, Kusunoki T, Oktay MF, Fukushima N, et al. Cochlear changes in patients with type 1 diabetes mellitus. Otolaryngology-Head and Neck Surgery. Jul 2005; 133(1): 100-6.

Ottaviani F, Dozio N, Neglia CB, Riccio S, Scavini M. Absence of otoacoustic emissions in insulin-dependent diabetic patients: is there evidence for diabetic cochleopathy?. Journal of Diabetes and its Complications. 1 Sep 2002; 16(5): 338-43.

Hilali A, Das V, Boulton A. A study of otoacoustic emissions in type 1 diabetes mellitus. Audiological Medicine. 1 Jan 2003; 1(4): 255-60.

Moghaddam YJ. Acoustic emissions from the inner ear and brain stem responses in type 2 diabetics. International journal of general medicine. 2011; 4: 871.

Abo-Elfetoh NM, Mohamed ES, Tag LM, El-Baz MA, Eldeen ME. Auditory dysfunction in patients with type 2 diabetes mellitus with poor versus good glycemic control. The Egyptian Journal of Otolaryngology. Jul 2015; 31(3): 162-9.

Zivkovic-Marinkov E, Milisavljevic D, Stankovic M, Zivic M, Bojanovic M. Is there a direct correlation between the duration and the treatment of type 2 diabetes mellitus and hearing loss?.Hippokratia. Jan 2016; 20(1): 32.

Park MS, Park SW, Choi JH. Distortion product otoacoustic emissions in diabetics with normal hearing. Scandinavian Audiology. 1 Jan 2001; 30(1): 148-51.

Di Nardo W, Ghirlanda G, Paludetti G,et.al. Distortion-product otoacoustic emissions and selective sensorineural loss in IDDM. Diabetes care. 1 Aug 1998; 21(8): 1317-21.

Eren E, Harman E, Arslanoğlu S, Önal K. Effects of type 2 diabetes on otoacoustic emissions and the medial olivocochlear reflex. Otolaryngology--Head and Neck Surgery. Jun 2014; 150(6): 1033-9.

Ren J, Zhao P, Chen L, Xu A, Brown SN, Xiao X. Hearing loss in middle-aged subjects with type 2 diabetes mellitus. Archives of medical research. 1 Jan 2009; 40(1): 18-23.