Diabetes mellitus quality care management: The promise of herbal supplementation

Arar  K; Ghouini  A

doi:10.30574/gscarr.2021.9.1.0197

Authors

Arar K Faculty of Medicine, University Blida, Algéria.
Ghouini A Hospital center Frantz Fanon, Blida, Algeria.

DOI:

https://doi.org/10.30574/gscarr.2021.9.1.0197

Keywords:

Diabetes, Insulin, Oral antidiabetics, Nutrition, Herbal medicine

Abstract

Overcoming diabetes is a major health challenge of the 21st century. WHO predicts that by 2030 it will be the seventh leading cause of death in the world and calls for global action to stop its rise and improve care. Actually, Herbal and nutritional supplementation is required in the management of diabetic patients, a finding shared unanimously by scientists. Recently diabetologists have come to the evidence that a therapeutic supplement consisting of nutrients and herbal is necessary to optimize the treatment of diabetes. The treatment of Type 2 diabetes mellitus, which is very often associated with overweight, is based on hygiene and dietetic measures and, where appropriate, on taking oral antidiabetics .This review describes the therapeutic arsenal of conventional oral antidiabetic drugs and emphasizes on innovative therapeutic option introducing herbal medicine and nutrition to the management of diabetic patients. Recent studies showed interesting potential in the reduction of blood sugar for many herbal for example Cinnamon, also berberine has been linked to the reduction of blood glucose levels, insulin levels and showed to be as effective as metformin, the most commonly prescribed drug for diabetics, at controlling blood sugar levels in diabetics. Moreover, a medicinal plant or herbal mixture can provide multi-targeted therapeutic action due to its complex chemical composition with hundreds of active ingredients such as oligosaccharides, alkaloids, polyphenols, flavonoids, tannins and at the same time ensure safety for the patients. We conclude by the fact that herbal and nutritional supplementation can bring major and promising progress in order to improve the patient care, by slowing the progression of type 2 diabetes and limiting its complications.

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References

American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. Diabetes Care. 2021; 44(Suppl. 1):S15–S33.

Evert AB, Dennison M, Gardner CD, Garvey WT, Lau KHK, MacLeod J, et al. Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report. Diabetes Care. 2019; 42(5): 731‑54.

Fraysse A. The combination of nutrition and herbal medicine to bring balance to diabetic conditions. 1. J Diabetol, 2019; 3: 34.

Grimaldi. A. Traité de Diabétologie. Flammarion Médecine Science. 2009.

Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010; 107(9): 1058-1070.

Scheen AJ, Charbonnel B. Effets antidiabétiques des thiazolidinediones. Médecine Thérapeutique. 2001; 7(9): 672‑9.

Nissen SE, Wolski K. Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes. N Engl J Med. 2007; 356(24): 2457‑71.

Jayakumar G, Ajithabai MD, Sreedevi S, Viswanathan PK, Remeshkumar B. Ethnobotanical survey of the plants used in the treatment of diabetes. 2010; 9(1): 100-104.

Scheen A-J. Antidiabétiques oraux dans le traitement du diabète de type 2 : perspectives historique et médico-économique. Médecine Mal Métaboliques. 2015; 9(2): 186‑97.

Monnier L, Colette C. Échec des antidiabétiques oraux à doses maximales tolérées : Quels traitements injectables? Médecine Mal Métaboliques. 2016; 10(2): 121‑30.

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). The Lancet. 1998; 352(9131): 837‑53.

Cotonou B. Étude ethnobotanique des plantes utilisées dans le traitement du diabète chez les femmes enceintes à Cotonou et Abomey-Calavi (Bénin). J Anim Plant Sci. 2013; 18(1): 2647‑58.

Eddouks M, Ouahidi ML, Farid O, Moufid A, Khalidi A, Lemhadri A. L’utilisation des plantes médicinales dans le traitement du diabète au Maroc. Phytothérapie. 2007; 5(4): 194‑203.

Bailey CJ, Turner RC. Metformin. N Engl J Med. 1996; 334(9): 574‑9.

Renjith RS, Chikku AM, Rajamohan T. Cytoprotective, antihyperglycemic and phytochemical properties of Cocos nucifera (L.) inflorescence. Asian Pac J Trop Med. 2013; 6(10): 804‑10.

Weng Y, Yu L, Cui J, Zhu Y-R, Guo C, Wei G, et al. Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats. J Ethnopharmacol. 2014; 152(3): 553‑60.

Pereira FL, Oliveira VB, Viana CT, Campos PP, Silva MA, Brandão MG. Antihyperlipidemic and antihyperglycemic effects of the Brazilian salsaparrilhas Smilax brasiliensis Spreng.(Smilacaceae) and Herreria salsaparrilha Mart.(Agavaceae) in mice treated with a high-refined-carbohydrate containing diet. Food Res Int. 2015; 76: 366‑72.

Zhang L, Tu Z, Xie X, Lu Y, Wang Z, Wang H, et al. Antihyperglycemic, antioxidant activities of two Acer palmatum cultivars, and identification of phenolics profile by UPLC-QTOF-MS/MS: new natural sources of functional constituents. Ind Crops Prod. 2016; 89: 522‑32.

Guang-Kai XU, Xiao-Ying QIN, Guo-Kai W, Guo-Yong XIE, Xu-Sen LI, Chen-Yu SUN, et al. Antihyperglycemic, antihyperlipidemic and antioxidant effects of standard ethanol extract of Bombax ceiba leaves in high-fat-diet-and streptozotocin-induced Type 2 diabetic rats. Chin J Nat Med. 2017; 15(3): 168‑77.

Schlienger J-L. Diabète et phytothérapie: les faits. Médecine Mal Métaboliques. 2014; 8(1): 101‑6.

Campbell IW. Antidiabetic drugs present and future. Drugs. 2000; 60(5): 1017‑28.

Ouchfoun M. Validation des effets antidiabétiques de Rhododendron groenlandicum, une plante médicinale des Cri de la Baie James, dans le modèle in vitro et in vivo: élucidation des mécanismes d’action et identification des composés actifs. 2011.

Boudjelthia K, Hammadi K, Kouidri M, Djebli N. Evaluation of antidiabetic activity of two plants Berberis vulgaris and Zygophyllum geslini. J Phys Chem Biophys. 2017;7(1):1–7

Ovalle-Magallanes B, Medina-Campos ON, Pedraza-Chaverri J, Mata R. Hypoglycemic and antihyperglycemic effects of phytopreparations and limonoids from Swietenia humilis. Phytochemistry. 2015; 110: 111–9.

Weng Y, Yu L, Cui J, Zhu Y-R, Guo C, Wei G, et al. Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats. Journal of Ethnopharmacology. 2014;152(3):553–60.

Ahmed S, Al-Rehaily AJ, Ahmad MS, Yousaf M, Nur-e-Alam M, Parvez MK, et al. Chemical constituents from Oncocalyx glabratus and their biological activities. Phytochem Lett. 2017; 20: 128‑32.

Okon UA, Umoren IU. Comparison of antioxidant activity of insulin, Ocimum gratissimum L., and Vernonia amygdalina L. in type 1 diabetic rat model. J Integr Med. 2017; 15(4): 302‑9.

El Ghoul J, Ghanem-Boughanmi N, Ben-Attia M. Biochemical study on the protective effect of ethanolic extract of Zygophyllum album on streptozotocin-induced oxidative stress and toxicity in mice. Biomed Prev Nutr. 2011; 1(2): 79‑83.

Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine. 2002; 9(1): 69‑74.

Langford SD, Boor PJ. Oleander toxicity: an examination of human and animal toxic exposures. Toxicology. 1996; 109(1): 1‑13.

Miller J, Deutsch J, Kang S. Food studies. Introd Res Methods. 2009.

Brusotti G, Cesari I, Dentamaro A, Caccialanza G, Massolini G. Isolation and characterization of bioactive compounds from plant resources: The role of analysis in the ethnopharmacological approach. J Pharm Biomed Anal. 2014; 87: 218‑28.

Sasidharan S, Chen Y, Saravanan D, Sundram KM, Latha LY. Extraction, isolation and characterization of bioactive compounds from plants’ extracts. Afr J Tradit Complement Altern Med. 2011; 8(1).

Bharti SK, Krishnan S, Kumar A, Rajak KK, Murari K, Bharti BK, et al. Antidiabetic activity and molecular docking of fructooligosaccharides produced by Aureobasidium pullulans in poloxamer-407-induced T2DM rats. Food Chem. 2013; 136(2): 813‑21.

Deters B, Saleem M. Hyperinsulinemia, cancer and maqui berry: The promise of nutritional supplementation. Food Sci Hum Wellness. 2019; 8(3): 264‑7.