Naja nubiae venom ameliorate hepatorenal toxicity induced by Gentamicin in rats

Ayman S  Mohamed; Hanan Farag El  Sayed; Nagat Saleh Hossuin  Moftha; Abdeljalil Mohamed Al  Shawoush

doi:10.30574/gscarr.2021.9.3.0290

Authors

Ayman S Mohamed Zoology Department - Faculty of Science - Cairo University, Giza, Egypt.
Hanan Farag El Sayed Zoology Department - Faculty of Science - Cairo University, Giza, Egypt.
Nagat Saleh Hossuin Moftha Department of zoology, Faculty of arts and sciences Alabyar, University of Benghazi, Libya.
Abdeljalil Mohamed Al Shawoush Zoology Department - Faculty of Science - Cairo University, Giza, Egypt.

DOI:

https://doi.org/10.30574/gscarr.2021.9.3.0290

Keywords:

Naja nubiae, Spitting cobra, Hepatorenal toxicity, Gentamycin, Venom

Abstract

Background: In developing countries, there is no doubt that acute kidney injury and chronic liver diseases have a major impact on health. Different venom components are gaining renewed interest as potential sources of new pharmacological compounds relevant for human therapeutics.

Aim: The present study was designed to evaluate the therapeutic efficacy of the crude venom extract of the Egyptian spitting cobra (Naja nubiae) venom extract against gentamycin–induced nephrotoxicity and hepatotoxicity in rats. Methods: Eighteen male Wistar rats were divided into three groups, control, gentamycin, and venom extract. The hepatorenal toxicity model was induced by gentamycin (80 mg/kg, intraperitoneal) for 8 days.

Results: LD50 of venom extract in rats was 0.2mg/kg. The venom extract group showed a significant decrease in the liver enzymes, urea, uric acid, creatinine, malondialdehyde meanwhile glutathione reduced and catalase levels increased. Histological examination of liver and kidney mild protective efficacy with less extensive degenerative changes in the tissues of venom extract grou

Conclusion: The results of the present investigation showed that administration of venom extract proved therapeutic efficacy against gentamycin -induced hepatorenal dysfunction by maintain the normal functional status of the liver and kidney and normalized the antioxidant system.

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References

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