Study of serum ghrelin and resistin levels and their correlation with zinc and magnesium in men with type 2 diabetes

Sinda  Ennigrou; Faika Ben  Mami; Kamel Ben  Mahrez; Chiheb Ben  Rayana; Fethi Ben  Slama

doi:10.30574/gscarr.2021.9.3.0297

Authors

Sinda Ennigrou Faculty of Pharmacy of Monastir.
Faika Ben Mami Head of Diabetology and Therapeutic Dietetics - National Institute of Nutrition.
Kamel Ben Mahrez Director of the Research Laboratory of Biochemistry and Technobiology Faculty of Sciences of Tunis - LR01ES05.
Chiheb Ben Rayana Faculty of Pharmacy of Monastir - Clinical Biochemistry Laboratory - National Institute of Nutrition.
Fethi Ben Slama Director of Nutrition Department - Higher School of Health Sciences and Techniques of Tunis.

DOI:

https://doi.org/10.30574/gscarr.2021.9.3.0297

Keywords:

Diabetes, Zinc, Magnesium, Ghrelin, Resistin

Abstract

Introduction: The objectives of our work were to compare the serum concentrations of lipid parameters,insulin, resistin, ghrelin, zinc and magnesium between two groups of men with obese type 2 diabetes and a control group and to study possible correlations between these differentparameters.

Material and methods: This was a monocentric case-control study during the period 19 October 2015 to 18 November 2015. It included biological parameters from two separate samples: a group of 41 male, obese, type 2 diabetic patients and a group of 34 diabetes-free controls.

Results: Mean plasma ghrelin concentrations were significantly lower in patients with type 2 diabetes compared to those in the control group: (14.05 ± 2.35 pg/mL) versus (45.45 ± 13.59 pg/mL). Mean resistance was significantly higher in diabetics (10.09 ± 2.63 ng/mL) compared to healthy subjects (2.22 ± 0.58 ng/mL). In multivariate analysis, body mass index (BMI) and insulin levels were factors that could influence zincemia variability, while BMI and ghrelinaemia appeared to be predictors of magnesium variability.

Discussion: Most correlation studies are based on serum zinc concentration. The different possible correlations between resistin, zinc, magnesium and ghrelin require an increase in the size of the study population, as well as an increase in nutritional surveys during the different stages of type 2 diabetes and obesity.

Conclusion: It would be interesting to evaluate, according to the stages of obesity, serum levels of magnesium and ghrelin, on the one hand, and serum levels of zinc and insulin, on the other hand.

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References

Falmer A, Fox R. Diagnosis, classification and treatment of diabetes. BMJ. 2011; 342: d3319.

Goldenberg R, Punthakee Z. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Can J Diabetes. 2013; 37: S369-72.

Chen N, Zhou L, Zhang Z, Xu J, Wan Z, Qin L. Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue. Regul Pept. 2014; 194-195: 49-54.

Germain-Zito N, Galusca B, Estour B. Physiology of ghrelin. Med Mal Metab. 2008; 2(3): 253-9.

Disse E. Ghrelin: physiology and therapeutic perspectives. A key player in food regulation. Diab Obes. 2011; 6(53): 357-64.

Praveena S, Pasula S, Sameera K. Trace elements in diabetes mellitus. J Clin Diagn Res. 2013; 7(9): 1863-65.

Badran M, Morsy R, Soliman H, Elnimr T. Assessment of trace elements levels inpatientswithtype 2 diabetesusingmultivariate statisticalanalysis. J Trace Elem Med Biol. 2016; 33: 114-19.

Safi S, Balouch L, Hassikou H, Sbiti M, Ait Lhaj H, Bamou Y, et al. Magnesium status in a Moroccan population of type 2 diabetic patients. Cah Nutr Diet. 2017; 42(1): 37-41.

Faucher P, Poitou C. Pathophysiology of obesity. Rheumatism Review Monographs. 2015.

Sedgwick P. Correlation. BMJ. 2012; 345: e5407.

Sedgwick P. Multiple regression. BMJ. 2013; 347: f4373.

Papoz L, Ben Khalifa F, Eschwege E, Ben Ayed H. Diabetes mellitus in Tunisia : description in urban and rural populations. Int J Epidemiol. 1988; 17: 419-22.

International Diabetes Federation (IDF). IDF Diabetes Atlas. 8Th Edition. 2017.

Doddigarla Z, Parwez I, Ahmad J. Correlation of serum chromium, zinc, magnesium and SOD levels with HbA1c in type 2 diabetes : a cross sectional analysis. Diabetes and Metabolic Syndrome. Clin Res Rev. 2016; 10S:S126-29.

Abdesselem H, Sebai I, Jemal M, Ounaissa K, Kandara H, Kammoun I, et al. Study of the correlation between insulin sensitivity and anthropometric and metabolic parameters in type 2 diabetes. Ann Cardiol Angeiol. 2017.

Gouaref I, Bellahsene Z, Zekri S, Alamir B, Koceir EA. Association of trace mineral profile with metabolic syndrome and oxidative stress in essential hypertension with or without type 2 diabetes. Ann Biol Clin. 2016;74(2):233-43.

Kaur J, Singh T. Estimation of serum magnesium and zinc levels in type-2- diabetes mellitus. Int J Bioassays. 2015;4(1):3654-56.

Pujar S, Pujar LL, Ganiger A, Hiremath K, Mannangi N, Bruthal M. Correlation of serum zinc, magnesium and copper with HbA1c in type 2 diabetes mellitus patients among Bagalkot population-A case control Study. Medica Innovatica. 2014;3(2):4-8.

Eva H, Akhter QS, Alam MK. Serum zinc and manganese levels in subjects with type 2 diabetes mellitus. J Bengladesch Soc Physiol. 2016;11(2):50-3.

Saha-Roy S, Bera S, Choudhury KM, Pal S, Bhattacharya A, Gargi S, et al. Status of serum magnesium, zinc & copper in patients suffering from type-2 diabetes mellitus. J Drug Deliv and Therapeutics. 2014;4(1):70-2.

Gharibeh MY, Al Tawallbeh GM, Abboud MM, Radaideh A, Alhader AA, Khabour OF. Correlation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients. Diabetes Metab. 2010; 36:443-49.

Zizzari P, Bluet-Pajot MT. Ghrelin, from GH secretagogue to orexigenic peptide. Metab Horm Diabetes Nut. 2004;8(2):58-65.

Yong Seok J, Dong Jin H, Yun Joung Y, Ji Hyun P, DaeYeol L. Serum ghrelin concentrations in type 2 diabetes mellitus. J Kor Soc Ped Endocrinol. 2004;9(1):59-65.

Al-Jboori MJ, Al-Saadi AH, Al-Saadi HK. Association ghrelin level with insulin resistance in type 2 diabetes mellitus obese patients. Med J Babylon. 2016;13(1): 184-95.

Dasarathan R, Kumar SS, Ganesh V, Chenthil KS. Study of serum zinc status among type 2 diabetes mellitus patients. Int J Adv Med. 2017; 4:1344-7.